Smad1/5 is acetylated in the dorsal aortae of the mouse embryo driving early arterial gene expression

Medicine, Cardiovascular System, Life Sciences, Cell Biology,
Smad1/5 signalling   arteriovenous differentiation   protein acetylation   embryonic development   arterial gene expression  

Academic Background During embryonic development, arteriovenous differentiation (AV differentiation) is a critical step in ensuring proper blood vessel formation and maturation. Defects in arterial or venous identity can lead to inappropriate fusion of vessels, resulting in so-called arteriovenous malformations (AVMs). Currently, the mechanism behi...

Circulating Dimethylguanidino Valeric Acid, Dietary Factors, and Risk of Coronary Heart Disease

Medicine, Cardiovascular System,
Dimethylguanidino Valeric Acid   Coronary Heart Disease   Dietary Factors   Metabolic Abnormalities   Biomarker  

Background Coronary Heart Disease (CHD) is one of the leading causes of death globally, with a complex pathogenesis involving multiple metabolic and dietary factors. In recent years, the development of metabolomics has provided new perspectives for studying CHD, particularly through the analysis of blood metabolites to uncover potential disease ris...

RNA Binding Protein with Multiple Splicing (RBPMS) Promotes Contractile Phenotype Splicing in Human Embryonic Stem Cell-Derived Vascular Smooth Muscle Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry,
RNA binding protein   vascular smooth muscle cells   splicing   embryonic stem cells   contractile phenotype  

The Critical Role of RNA-Binding Protein RBPMS in Vascular Smooth Muscle Cells Academic Background Vascular Smooth Muscle Cells (VSMCs) are the primary structural components of large arteries. In healthy blood vessels, VSMCs exhibit a mature contractile phenotype, responsible for regulating vascular tone and blood flow. However, VSMCs possess pheno...

Management of High-Risk Acute Pulmonary Embolism: An Emulated Target Trial Analysis

Medicine, Respiratory System, Emergency Medicine, Cardiovascular System,
High-risk pulmonary embolism   Systemic thrombolysis   Surgical thrombectomy   Percutaneous catheter-directed treatment   Mechanical circulatory support  

Target Trial Emulation Analysis for the Management of High-Risk Acute Pulmonary Embolism Background Introduction Acute pulmonary embolism (PE) is a life-threatening cardiovascular disease affecting more than 35 people per 100,000 annually. Approximately 5% of PE patients present with persistent hypotension, cardiogenic shock, or cardiac arrest, oft...

Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury in Critical Care

Medicine, Nephrology, Cardiovascular System, Life Sciences, Biochemistry,
major cardiovascular surgery   metabolism   metabolomics   amino acid   TCA cycle   citric acid   acylcarnitines   acute kidney injury  

The Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury: A Metabolomics Study Academic Background Cardiovascular diseases are the leading cause of death worldwide, accounting for over 17.9 million deaths annually, which is 32% of all deaths. As the disease burden increases, about one-third of patients may req...

Imitation Learning for Path Planning in Cardiac Percutaneous Interventions

Engineering, Information Science, Artificial Intelligence, Medicine, Cardiovascular System, Life Sciences, Bioengineering,
path planning   imitation learning   cardiac surgery   robotic navigation   minimally invasive surgery  

Application of Imitation Learning in Path Planning for Percutaneous Cardiac Interventions Academic Background Cardiac valve diseases, particularly mitral regurgitation (MR), are the third most common type of valvular heart disease globally and have a higher incidence in the elderly population. MR is characterized by the incomplete closure of the mi...