Adult Human Heart Extracellular Matrix Improves Human iPSC-CM Function via Mitochondrial and Metabolic Maturation

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
extracellular matrix   iPSC-derived cardiomyocyte   functional maturation   mitochondrial maturation   metabolic maturation   cell therapy  

1. Academic Background Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide. After a myocardial infarction, up to one billion cardiomyocytes (CM) can be lost in just a few hours. However, adult myocardial tissue itself has extremely low regenerative capacity, which means the ...

Neonatal Apical Resection Preserves the Proliferative Capacity of Cardiomyocytes Throughout the Left Ventricle

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
apical resection   cardiomyocyte   cell-cycle   heart regeneration   heat shock protein   left ventricle   pig model  

I. Academic Background: The Cardiac Mystery Facing Regenerative Medicine Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide due to heart damage. However, the adult mammalian heart has long been regarded as having essentially lost its endogenous regenerative ability, with th...

Development and Validation of a Proteomic Signature of Healthspan

Medicine, Environmental and Public Health, Medical Laboratory Science, Geriatrics, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
healthspan   proteomics   biological aging biomarkers   aging biomarkers   UK Biobank   healthy aging  

1. Academic Background: From Lifespan Extension to the Enhancement of Healthspan With the improvement of global medical and socioeconomic standards since the 20th century, overall human lifespan has significantly increased, especially in developing countries. However, healthspan—the number of years an individual lives in a state of complete health,...

METTL3 Mediates Atheroprone Flow–Induced Glycolysis in Endothelial Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology,
glycolysis   endothelial cells   atherosclerosis   METTL3   flow   RNA modification   metabolic reprogramming  

1. Research Background Atherosclerosis is the primary pathological basis of cardiovascular diseases, closely associated with endothelial cell (EC) dysfunction. Hemodynamic factors play a critical role in the regional selectivity of atherosclerosis: oscillatory shear stress (OS) (e.g., at vascular bifurcations) promotes plaque formation, while pulsa...

Modulation of Bone Marrow Haematopoietic Stem Cell Activity as a Therapeutic Strategy After Myocardial Infarction: A Preclinical Study

Medicine, Hematology, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
myocardial infarction   bone marrow haematopoietic stem cells   inflammation   vitamin A metabolites   cardiac function  

Academic Background Myocardial Infarction (MI) is one of the major global health concerns. Although myeloid cells in the bone marrow (BM) are crucial for tissue repair after MI, excessive myelopoiesis can exacerbate scarring and impair cardiac function. Hematopoietic stem cells (HSCs) in the bone marrow possess unique regenerative capabilities, ena...

Sugarcane Wax-Based Solid Lipid Nanoparticles as an Atorvastatin Carrier: Characterization and In Vivo Evaluation of Antihyperlipidemic Activity in Rats

Chemistry, Medicinal Chemistry, Medicine, Pharmacy, Cardiovascular System,
Sugarcane wax   Solid lipid nanoparticles   Atorvastatin   In vivo studies   Antihyperlipidemic  

Academic Background Cardiovascular diseases, particularly atherosclerosis, are one of the leading causes of death globally. Elevated cholesterol levels are a major risk factor for atherosclerosis. Atorvastatin (ATV) is a widely used cholesterol-lowering drug, but its oral bioavailability is low, primarily due to first-pass metabolism. To improve th...