Sugarcane Wax-Based Solid Lipid Nanoparticles as an Atorvastatin Carrier: Characterization and In Vivo Evaluation of Antihyperlipidemic Activity in Rats

Chemistry, Medicinal Chemistry, Medicine, Pharmacy, Cardiovascular System,
Sugarcane wax   Solid lipid nanoparticles   Atorvastatin   In vivo studies   Antihyperlipidemic  

Academic Background Cardiovascular diseases, particularly atherosclerosis, are one of the leading causes of death globally. Elevated cholesterol levels are a major risk factor for atherosclerosis. Atorvastatin (ATV) is a widely used cholesterol-lowering drug, but its oral bioavailability is low, primarily due to first-pass metabolism. To improve th...

An Electromechanical Model-Based Study on the Dosage Effects of Ranolazine in Treating Failing HCM Cardiomyocyte

Medicine, Cardiovascular System,
Electromechanical characteristics   Cardiomyocyte   Hypertrophic cardiomyopathy   Heart failure   Ranolazine   Computational model  

Hypertrophic Cardiomyopathy (HCM) is a common inherited heart disease, affecting approximately 1 in 500 people globally. The primary characteristic of HCM is asymmetric hypertrophy of the myocardium. In its early stages, it may manifest as hyperdynamic contraction of the left ventricle (LV). However, as the disease progresses, patients may develop ...

Development of a Method for Visualizing and Quantifying Thrombus Formation in Extracorporeal Membrane Oxygenators

Medicine, Medical Imaging, Cardiovascular System, Life Sciences, Bioengineering,
thrombosis   medical device-associated thrombosis   extracorporeal membrane oxygenation   computed tomography   biomaterials  

Extracorporeal Membrane Oxygenation (ECMO) is a life-support technology used for patients with cardiac and respiratory failure. Although ECMO plays a crucial role in clinical practice, its use is accompanied by significant risks of medical device-associated thrombosis. Thrombosis not only obstructs blood flow in the oxygenator but also reduces gas ...

Mechanical Trapping of the Cell Nucleus into Microgroove Concavity but not on Convexity Induces Cell Tissue Growth and Vascular Smooth Muscle Differentiation

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Bioengineering,
cell biomechanics   mechanobiology   vascular smooth muscle cell   differentiation   microfabrication  

Academic Background Vascular Smooth Muscle Cells (VSMCs) in the normal aortic wall regulate vascular contraction and dilation. However, under pathological conditions, VSMCs transition from a contractile phenotype to a synthetic phenotype and actively participate in the remodeling of the aortic wall. Although many in vitro studies have reported the ...

Phenotypic Age Mediates Effects of Life’s Essential 8 on Reduced Mortality Risk in US Adults

Medicine, Environmental and Public Health, Geriatrics, Cardiovascular System,
Phenotypic Age   Life’s Essential 8   All-Cause Mortality   Cardiovascular Mortality   Mediation   Healthy Lifestyle   Biological Aging  

Aging is one of the major risk factors for a variety of chronic diseases and death. However, chronological age does not fully reflect individual differences in the biological aging process. Phenotypic age is a composite score based on routine clinical markers, used to differentiate individuals within the same age group who have varying risks of dis...

The Effects of Fermented Vegetables on the Gut Microbiota for Prevention of Cardiovascular Disease

Medicine, Gastroenterology, Cardiovascular System, Life Sciences, Biochemistry, Microbiology,
gut microbiota   cardiovascular disease   fermented vegetables   inflammation   C-reactive protein  

In recent years, the role of gut microbiota in health and disease has garnered widespread attention. Research indicates that the diversity and composition of gut microbiota are closely related to the development and progression of cardiovascular disease (CVD). CVD is one of the leading causes of death globally, and inflammation plays a significant ...