Prevalence and Incidence of Comorbidities in Patients with Atopic Dermatitis, Psoriasis, Alopecia Areata, and Vitiligo Using a Japanese Claims Database

Medicine, Infectious Diseases, Rheumatology and Immunology, Oncology, Cardiovascular System, Life Sciences, Immunology,
comorbidities   atopic dermatitis   psoriasis   alopecia areata   vitiligo   Japan   health claims database  

Prevalence and Incidence of Comorbidities in Japanese Patients with Dermatologic Diseases Academic Background Dermatologic diseases such as atopic dermatitis (AD), psoriasis, alopecia areata (AA), and vitiligo are common chronic inflammatory or autoimmune skin disorders. These conditions not only significantly impact patients’ quality of life but a...

Bioprinted Micro-Clots for Kinetic Analysis of Endothelial Cell-Mediated Fibrinolysis

Medicine, Medical Laboratory Science, Hematology, Pharmacy, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Biophysics,
bioprinting   micro-clots   fibrinolysis   endothelial cells   venous thromboembolism   drug testing   high-throughput analysis  

Breakthrough Research on Micro-Scale Exploration of Thrombolysis Kinetics Research Background and Problem Venous thromboembolism (VTE), a severe health condition, causes approximately 500,000 deaths annually in the United States alone. The occurrence of VTE is closely related to the formation and resistance to dissolution of thrombi in veins, commo...

Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
bioprinting   vascularization   skeletal muscle flaps   volumetric muscle loss   tissue engineering   perfusion   transplantation  

Academic Report on “Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss” Background Muscle tissues constitute a significant portion of human cellular mass and are a complex, highly vascularized, and dynamic tissue. However, traumatic or surgical Volumetric Muscle Loss (VML)—defined as the loss o...

An Organotypic Atlas of Human Vascular Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
vascular cells   single-cell transcriptomics   endothelial cells   mural cells   organotypic   molecular signatures   vascular diseases  

Decoding the Human Vascular System: A Comprehensive Multi-organ Single-cell Transcriptomic Study Reveals Vascular Cell Diversity Background Overview The human vascular system is a core component for sustaining life, comprising endothelial cells (ECs) and mural cells that span across all organ systems. Its functions extend beyond merely delivering b...

Deep Phenotyping of Testosterone-Prompted Fibrosis in Arrhythmogenic Right Ventricular Cardiomyopathy Using iPSC-Derived Engineered Cardiac Spheroids

Medicine, Cardiovascular System, Life Sciences,
Arrhythmogenic Right Ventricular Cardiomyopathy   Gender Difference   Cardiac Spheroids   Testosterone   Fibrosis   iPSC   Cardiac Fibrosis  

iPSC-Derived Engineered Cardiac Spheroids Reveal the Fibrotic Role of Testosterone in Arrhythmogenic Right Ventricular Cardiomyopathy Academic Background Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by the replacement of myocardial tissue with adipose and fibrous tissue, leading to arrhythmias,...

Novel Heart Valve Leaflet Designs with Stiff Polymeric Materials and Biomimetic Kinematics

Materials Science, Organic Polymeric Materials, Medicine, Cardiovascular System, Life Sciences, Bioengineering,
heart valve   polymeric materials   biomimetic design   hemodynamics   finite element analysis   in vitro testing   leaflet kinematics  

Novel Heart Valve Leaflet Design: Research Based on High-Stiffness Polymeric Materials and Biomimetic Kinematics Academic Background Heart valve disease is a significant global health issue, with over 850,000 patients requiring heart valve replacement surgery annually. Currently, the heart valves used in clinical practice are mainly divided into tw...