A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...
Academic Background: Exploring Perceptual Inference and Neural Mechanisms In everyday life, our sensory systems often encounter incomplete or ambiguous information. For instance, when objects are occluded, the brain relies on prior experience and expectations to infer the whole. This inferential ability is not only a core function of the human visu...
New Pathway for ALS/FTD-Related C9orf72 Pathogenesis Revealed by Latest Nature Neuroscience Study Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are among the most challenging neurodegenerative diseases in clinical medicine, with complex pathogenesis that remains insufficiently expl...
1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...
Unveiling the Mystery of the Epigenetic Aging Clock: A Review of Research on the Impact of Epigenetic Editing at Single Age-Associated CpG Sites on the Genome-wide Epigenetic Aging Landscape I. Research Background and Scientific Questions Epigenetics, especially DNA methylation, has become a cutting-edge frontier in aging mechanism research in rece...
1. Research Background and Scientific Problem The health of the hematopoietic system is crucial to the proper functioning of the body, with hematopoietic stem cells (HSCs) at its core in maintaining normal blood system operation. HSCs possess self-renewal and multipotent differentiation abilities, capable of generating all types of blood cells, inc...
Molecular Mechanisms of Gut Microbiota and Its Metabolites Mediating Endothelial Cell Senescence During Aging – Interpretation of Latest Results from Nature Aging I. Research Background and Significance Against the backdrop of a deeply aging human society, cardiovascular disease (CVD) has become one of the greatest health threats to the global elde...