Background Research Background: Both intrinsic and extrinsic factors in the tumor microenvironment (TME) can lead to treatment resistance. This paper reveals that the Transforming Growth Factor (TGF)-β1 produced within the TME increases drug resistance in neuroblastoma (NB) cells. Drug resistance is the main cause of cancer treatment failure, usual...

Improved Segmentation of Pediatric Low-Grade Gliomas Through Multitask Learning Background Introduction The segmentation of pediatric brain tumors is a critical task in tumor volume analysis and artificial intelligence algorithms. However, this process is time-consuming and requires the expertise of neuroradiologists. Although significant research ...

St. Jude Survivorship Portal: Analysis and Sharing of Large-Scale Clinical and Genomic Data of Pediatric Cancer Survivors Research Background In the United States, the five-year survival rate for childhood cancer has increased from about 60% in the 1970s to over 85% today. Despite the significant improvement in survival rates, these childhood cance...

Research Background γδ T cells play an important role in the immune system, particularly in protective immunity, homeostasis, and tissue repair. Unlike conventional αβ T cells, which are restricted by major histocompatibility complex (MHC), γδ T cells directly seed peripheral tissues and respond to various microbial stimuli without relying on MHC-p...

Language and Sensory Characteristics of Very Low Birth Weight Children in Response to Sound Background and Motivation Very Low Birth Weight (VLBW) children face higher risks of cognitive developmental obstacles, including language deficits and sensory-motor difficulties. Previous studies have indicated that sound-evoked brain responses (P1m) can se...