Actionability and Familial Uptake Following Opportunistic Genomic Screening in a Pediatric Cancer Cohort

Feasibility Study of Opportunistic Genomic Screening in Pediatric Cancer Patients and Its Family Acceptance Research Background With the development and application of genomic medicine, the care for patients with severe diseases is gradually being optimized. Especially in the field of childhood cancer, whole-genome series DNA testing has become an ...

Quantitative expression of latent disease factors in individuals associated with psychopathology dimensions and treatment response

Quantitative expression of latent disease factors in individuals associated with psychopathology dimensions and treatment response

Study on Quantitative Expression and Treatment Response of Latent Disease Factors Underlying Psychopathological Dimensions Revealed by Unsupervised Machine Learning Research Background Heterogeneity and comorbidity are prevalent in psychiatric diagnoses, posing challenges for precise diagnosis and personalized treatment. For instance, Autism Spectr...

Computational Modeling of the Prefrontal-Cingulate Cortex to Investigate the Role of Coupling Relationships for Balancing Emotion and Cognition

Computational Modeling of the Prefrontal-Cingulate Cortex to Investigate the Role of Coupling Relationships for Balancing Emotion and Cognition

Computational Modeling of Prefrontal-Cingulate Coupling: Exploring Its Role in Balancing Emotion and Cognition Academic Background In recent years, emotional processing and cognitive control, which are crucial for maintaining normal social behavior and executive function, have attracted widespread attention. This study explores how the balance betw...

Mapping the Behavioral Signatures of Shank3B Mice in Both Sexes

Behavioral Characterization of Shank3B Mice Across Both Sexes Research Background Autism Spectrum Disorder (ASD) is a group of complex mental disorders characterized by abnormalities in social interaction and repetitive behaviors. The Shank3B mutant ASD mouse model is widely used in research; however, the behavioral phenotype of this model has not ...

Neural Basis of Categorical Representations of Animal Body Silhouettes

Neural Mechanism | Neural Basis of Animal Body Silhouette Classification This article, written by Yue Pu and Shihui Han, published in “neurosci. bull.” in 2024, explores the neural processes of rapid classification and cognition of animal body silhouettes in humans. The study aims to reveal how humans identify and categorize individuals of differen...