Resting State Functional Connectivity of the Default Mode Network During Opioid Use and Cessation in Treatment-Seeking Persons

Medicine, Psychiatry, Neurology, Medical Imaging,
resting-state functional connectivity   default mode network   opioid use disorder   withdrawal symptoms   neuroimaging   addiction mechanisms   relapse prediction  

Functional Connectivity of the Default Mode Network During Opioid Use and Cessation Background Opioid abuse has become a global public health issue, particularly in the United States, where opioid overdose deaths have tripled since 1999. Opioids not only lead to addiction but are also associated with chronic pain, immune system suppression, and neu...

The Serotonergic Psychedelic DOI Impairs Deviance Detection in the Auditory Cortex

Medicine, Psychiatry, Neurology, Clinical Psychology,
auditory cortex   deviance detection   psychedelics   serotonin   neural response variability  

The Impairment of Deviance Detection in the Auditory Cortex by DOI Academic Background Psychedelics are a class of psychoactive substances that can significantly alter perception, cognition, and mood. In recent years, psychedelics have shown potential applications in treating conditions such as depression, anxiety, and trauma-related disorders. How...

Neuroimaging Meets Neurophysiology: Are There Cortical Somatotopic Motor Maps Outside of the Human Precentral Gyrus?

Medicine, Psychiatry, Neurology, Clinical Psychology, Medical Imaging,
somatotopic motor maps   lateral occipitotemporal cortex   precuneus   functional MRI   motor control  

New Discoveries in Cortical Motor Maps Background Introduction Humans and other primates are capable of performing a wide range of complex body movements, the initiation and control of which rely on multiple cortical and subcortical structures. Among these, the primary motor cortex (M1), located in the precentral gyrus, is the core region for execu...

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus

Medicine, Psychiatry, Neurology, Neurosurgery, Clinical Psychology,
hydrocephalus   neuropsychology   cognition   research priorities   quality of life   clinical assessment   animal models  

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus Academic Background Hydrocephalus is a neurological disorder affecting approximately 85 per 100,000 individuals worldwide. It is closely associated with motor and cognitive impairments. Although advancements in surgical interventions have significantly impr...

Epigenome-Wide Association Studies Identify Novel DNA Methylation Sites Associated with PTSD: A Meta-Analysis of 23 Military and Civilian Cohorts

Medicine, Psychiatry, Life Sciences, Biochemistry, Genetics,
PTSD   DNA methylation   post-traumatic stress disorder   epigenetics   gene expression   meta-analysis   genome-wide association studies  

Epigenome-wide DNA Methylation Study Highlights PTSD-Associated Sites: A Meta-Analysis Across 23 Military and Civilian Cohorts Background and Research Objectives Post-Traumatic Stress Disorder (PTSD) is a serious psychiatric condition triggered by exposure to traumatic events. It is characterized by intrusive memories, avoidance or emotional numbne...