Establishing Functionally Segregated Dopaminergic Circuits

Functional Segregation of Dopaminergic Neural Circuits and Their Developmental Mechanisms Academic Background Dopamine is a crucial neurotransmitter in the brain, regulating various physiological functions, including motor control, emotional regulation, motivation, learning, and memory. Dopaminergic neurons are primarily located in the midbrain, an...

The Role of Electroencephalography in Epilepsy Research—From Seizures to Interictal Activity and Comorbidities

The Role of Electroencephalography in Epilepsy Research: From Seizures to Interictal Activity and Comorbidities Academic Background Since the early 20th century, electroencephalography (EEG) has been a key tool in epilepsy research. EEG technology not only helps scientists record and analyze brain signals but also reveals the pathophysiological mec...

A Cross-Tissue Transcriptome-Wide Association Study Identifies New Susceptibility Genes for Insomnia

A Cross-Tissue Transcriptome-Wide Association Study Identifies New Susceptibility Genes for Insomnia Background Insomnia is the second most prevalent psychiatric disorder, affecting nearly one-third of the global population. It not only diminishes quality of life but also increases the risk of cardiovascular diseases, metabolic disorders, mood diso...

The Serotonergic Psychedelic DOI Impairs Deviance Detection in the Auditory Cortex

The Impairment of Deviant Detection in the Auditory Cortex by the Serotonergic Psychedelic DOI Research Background Psychedelics are a class of psychoactive substances capable of significantly altering perception, cognition, and mood. They have recently regained attention due to their potential therapeutic value, such as in treating depression and a...

Machine Learning and Confirmatory Factor Analysis Show that Buprenorphine Alters Motor and Anxiety-like Behaviors in Male, Female, and Obese C57BL/6J Mice

In recent years, with the global increase in drug abuse, particularly opioids, scientists have become increasingly focused on the neurobehavioral effects of such substances. Among them, buprenorphine, an opioid, is widely used for medication-assisted treatment of opioid addiction. However, beyond its analgesic and addiction treatment effects, bupre...