Amelioration of Nonalcoholic Fatty Liver Disease by Inhibiting the Deubiquitylating Enzyme RPN11

Medicine, Hepatobiliary System, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
NAFLD   RPN11   deubiquitination   metabolic liver disease   lipid metabolism  

Study on the Suppression of Deubiquitinase Rpn11 to Improve Non-Alcoholic Fatty Liver Disease (NAFLD) Background Introduction Non-alcoholic fatty liver disease (NAFLD) and its more severe form, non-alcoholic steatohepatitis (NASH), have become major global public health issues. The rapid increase in their incidence has made them leading causes of c...

m6A mRNA Methylation in Brown Fat Regulates Systemic Insulin Sensitivity via an Inter-Organ Prostaglandin Signaling Axis Independent of UCP1

Medicine, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
brown fat   m6A methylation   insulin sensitivity   prostaglandin   lipid metabolism   METTL14   signaling  

The Role of m6A mRNA Methylation in Adipose Tissue: A Breakthrough Discovery of Cross-Organ Prostaglandin Signaling Axis in Insulin Sensitivity Regulation Research Background and Motivation In recent years, the potential role of brown adipose tissue (BAT) in human metabolic regulation has attracted widespread attention. Known for its thermogenic pr...

Acyl-CoA Binding Protein for the Experimental Treatment of Anorexia

Medicine, Psychiatry, Endocrinology, Neurology, Gastroenterology, Life Sciences, Biochemistry, Immunology,
Anorexia   Acyl-CoA Binding Protein   Diazepam Binding Inhibitor   Chronic Restraint Stress   Autophagy-dependent Secretion Pathway  

Introduction This report aims to reveal the recent research findings published by Hui Chen et al. in “Science Translational Medicine”, which explores the application of exogenous Acyl-Coenzyme A Binding Protein (ACBP) in Anorexia Nervosa. Anorexia Nervosa is a prevalent and difficult-to-treat eating disorder that primarily affects adolescents and y...

Leptin Receptor Reactivation Restores Brain Function in Early-Life lepr-Deficient Mice

Medicine, Basic Medical Sciences, Endocrinology, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry,
leptin   obesity   neurogenesis   memory impairment   brain atrophy  

Reactivation of Insulin Receptors Can Restore Brain Function in Early Lepr-Deficient Mice Background Obesity is a chronic disease caused by excessive fat accumulation, affecting both body and brain health. Deficiency of the insulin receptor (Leptin receptor, Lepr) is considered an important factor in the pathogenesis of obesity. Insulin plays a cru...

TM7SF3 Controls TEAD1 Splicing to Prevent MASH-Induced Liver Fibrosis

Medicine, Hepatobiliary System, Basic Medical Sciences, Endocrinology, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
TM7SF3   TEAD1   Liver fibrosis   MASH   HSC activation  

Background Introduction In modern society, metabolic dysfunction-associated steatotic liver disease (MASLD, previously NAFLD) is a common and serious chronic liver disease. However, the current understanding of its pathological mechanisms is not complete, including its progression to metabolic dysfunction-associated steatohepatitis (MASH), liver fi...

Short-Term Cold Exposure Induces Persistent Epigenomic Memory in Brown Fat

Medicine, Basic Medical Sciences, Urology, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
short-term cold exposure   epigenomic memory   brown fat   HDAC3   C/EBPβ   adaptive thermogenesis  

Short-term Cold Exposure Induces Persistent Epigenomic Memory in Brown Adipose Tissue Background Brown Adipose Tissue (BAT) is the primary non-shivering thermogenic organ in mammals that dissipates chemical energy as heat under cold stimuli. BAT is characterized by a high density of mitochondria containing Uncoupling Protein 1 (UCP1), which generat...