Role of Sirtuins in Obesity and Osteoporosis: Molecular Mechanisms and Therapeutic Targets

Medicine, Orthopedics, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
Sirtuins   Obesity   Osteoporosis   Mesenchymal stem cells   Gut microbiota   Insulin   Polyphenolic natural products  

The Role of Sirtuins in Obesity and Osteoporosis and Their Therapeutic Potential Academic Background Obesity and osteoporosis (OP) are increasingly severe public health issues worldwide. Obesity is not only closely related to metabolic diseases such as cardiovascular diseases and diabetes but also has a complex association with the occurrence of os...

Developmental Pluripotency-Associated 4 Increases Aggressiveness of Pituitary Neuroendocrine Tumors by Enhancing Cell Stemness

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Genetics,
pituitary neuroendocrine tumors   cell stemness   Wnt/β-catenin signaling   Dppa4 gene   tumor aggressiveness   epigenetics   stem cell regulation  

The Oncogenic Role of Dppa4 in Pituitary Neuroendocrine Tumors Academic Background Pituitary Neuroendocrine Tumors (PitNETs) are common intracranial tumors that often exhibit hormone-secreting functions and are a significant cause of hypogonadism and infertility in humans. Although most PitNETs can be controlled through surgery and medication, some...

A TBX2-Driven Signaling Switch from Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

Medicine, Urology, Endocrinology, Oncology,
prostate cancer   therapeutic resistance   TBX2   androgen receptor   glucocorticoid receptor   signaling switch   SP2509  

Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...

A Couple-Based Intervention for Chinese Older Adults with Type 2 Diabetes: A Randomized Clinical Trial

Medicine, Environmental and Public Health, Geriatrics, Endocrinology,
Type 2 Diabetes   Couple-Based Intervention   Randomized Clinical Trial   Older Adults   Glycemic Control   Quality of Life   Collective Efficacy  

Report on the Management of Chinese Older Adults with Type 2 Diabetes through Couple-Based Interventions: A Randomized Clinical Trial Academic Background Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic diseases globally, particularly common among older adults. China has the largest number of diabetes patients worldwide, reachin...

Diagnostic Accuracy and Value of CXCR4-Targeted PET/MRI Using 68Ga-Pentixafor for Tumor Localization in Cushing Disease

Medicine, Endocrinology, Neurosurgery, Medical Imaging,
Cushing Disease   68Ga-Pentixafor   PET/MRI   CXCR4   Tumor Localization   Diagnostic Accuracy   Pituitary Tumors  

Diagnostic Accuracy and Value of 68Ga-Pentixafor PET/MRI in Tumor Localization for Cushing’s Disease Academic Background Cushing’s disease is the primary cause of Cushing’s syndrome, characterized by excessive secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland, often due to pituitary adenomas. Patients with chronic hypercortis...

Revolutionary Self-Powered Transducing Mechanism for Long-Lasting and Stable Glucose Monitoring: Achieving Selective and Sensitive Bacterial Endospore Germination in Microengineered Paper-Based Platforms

Engineering, Electrical Engineering, Medicine, Endocrinology, Life Sciences, Bioengineering, Microbiology,
glucose monitoring   self-powered transduction   bacterial spore germination   microengineered platforms   diabetes management  

Revolutionary Self-Powered Glucose Monitoring Mechanism: Microengineered Paper-Based Platform with Microbial Spores Academic Background Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, which can lead to severe complications such as cardiovascular diseases, retinopathy, kidney failure, and neuropathy. The glob...