Phosphatidylinositol Promotes the Proliferation and Invasion of Pituitary Adenoma Cells by Regulating POU1F1 Expression

Medicine, Endocrinology, Oncology, Life Sciences, Biochemistry,
phosphatidylinositol   pituitary adenoma   POU1F1   metabolomics   proteomics   cell invasion   AKT/ERK signaling pathway  

Phosphatidylinositol Promotes Pituitary Adenoma Cell Proliferation and Invasion by Regulating POU1F1 Expression Background Pituitary adenoma (PA) is one of the most common primary intracranial tumors, accounting for approximately 15% of all intracranial tumors. Although most pituitary adenomas are benign, about 30% of them are invasive, known as in...

Similar Deficiencies, Different Outcomes: Succinate Dehydrogenase Loss in Adrenal Medulla vs. Fibroblast Cell Culture Models of Paraganglioma

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Succinate Dehydrogenase   Paraganglioma   Adrenal Medulla   Fibroblasts   Metabolism   Tumorigenesis   Hypoxic Signaling  

Different Manifestations of SDH Loss in Adrenal Medulla vs. Fibroblast Models Background Introduction Succinate dehydrogenase (SDH) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle and electron transport chain, responsible for oxidizing succinate to fumarate and participating in electron transfer. SDH consists of four subunits (S...

CYP19A1 Regulates Chemoresistance in Colorectal Cancer Through Modulation of Estrogen Biosynthesis and Mitochondrial Function

Medicine, Endocrinology, Gastroenterology, Oncology, Life Sciences, Biochemistry,
colorectal cancer   chemotherapy resistance   CYP19A1   mitochondria   mitochondrial respiratory chain complexes  

CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...

Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration

Chemistry, Medicinal Chemistry, Medicine, Orthopedics, Endocrinology, Pharmacy, Life Sciences, Biochemistry, Bioengineering,
drug delivery systems   bioresponsive   diabetic condition   microenvironment remodeling   vascularized bone regeneration  

Advanced Bioresponsive Drug Delivery Systems for Diabetic Vascularized Bone Regeneration Background The treatment of bone defects in patients with Diabetes Mellitus (DM) remains a significant challenge, as the diabetic microenvironment severely impedes bone regeneration. Various abnormal factors in the diabetic microenvironment, such as hyperglycem...

Insulin Activates Parasympathetic Hepatic-Related Neurons of the Paraventricular Nucleus of the Hypothalamus Through mTOR Signaling

Medicine, Endocrinology, Neurology,
insulin   paraventricular nucleus of the hypothalamus   parasympathetic   hepatic glucose production   mTOR signaling  

Insulin Activates Hepatic-Related Neurons in the Paraventricular Nucleus of the Hypothalamus via mTOR Signaling Academic Background Glucose homeostasis is a critical physiological process for sustaining life, with the liver playing a central role in this regulation. The liver maintains blood glucose levels by modulating glycogen production and gluc...

Impact of Glucagon-Like Peptide-1 Receptor Agonists on Axonal Function in Diabetic Peripheral Neuropathy

Medicine, Endocrinology, Neurology,
Diabetic Peripheral Neuropathy   Glucagon-Like Peptide-1 Receptor Agonists   Axonal Excitability   Nerve Conduction Studies   Na+/K+-ATPase Pump Function  

Impact of GLP-1 Receptor Agonists on Axonal Function in Diabetic Peripheral Neuropathy Academic Background Diabetic Peripheral Neuropathy (DPN) is one of the most common complications in patients with type 2 diabetes worldwide, affecting approximately 50% of diabetic patients. The main symptoms of DPN include neuropathic pain, numbness, and in seve...