Revolutionary Self-Powered Transducing Mechanism for Long-Lasting and Stable Glucose Monitoring: Achieving Selective and Sensitive Bacterial Endospore Germination in Microengineered Paper-Based Platforms

Engineering, Electrical Engineering, Medicine, Endocrinology, Life Sciences, Bioengineering, Microbiology,
glucose monitoring   self-powered transduction   bacterial spore germination   microengineered platforms   diabetes management  

Revolutionary Self-Powered Glucose Monitoring Mechanism: Microengineered Paper-Based Platform with Microbial Spores Academic Background Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, which can lead to severe complications such as cardiovascular diseases, retinopathy, kidney failure, and neuropathy. The glob...

A Prognostic Molecular Signature of Hepatic Steatosis is Spatially Heterogeneous and Dynamic in Human Liver

Medicine, Hepatobiliary System, Endocrinology, Gastroenterology,
hepatic steatosis   molecular signature   spatial heterogeneity   dynamic   liver   metabolic disease   biomarkers  

Academic Background Metabolic-associated Steatotic Liver Disease (MASLD) is a major health issue affecting over 30% of the global population and is closely related to various chronic diseases such as cancer, cardiovascular disease, and renal dysfunction. The pathological spectrum of MASLD ranges from simple steatosis to steatohepatitis and progress...

Cycling Alpha Cells in Regenerative Drug-Treated Human Pancreatic Islets May Serve as Key Beta Cell Progenitors

Medicine, Endocrinology, Life Sciences, Cell Biology,
regenerative drugs   alpha cells   beta cells   pancreatic islets   diabetes   cell differentiation   single-cell RNA sequencing  

Academic Background Diabetes is a global health issue affecting over 500 million people. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) share the common feature of a significant reduction in the number of functional insulin-secreting beta cells. Therefore, restoring or increasing beta cell mass is considered a key strategy in diabetes treatme...

Molecular Mechanism of Prolactin-Releasing Peptide Recognition and Signaling via its G Protein-Coupled Receptor

Molecular Mechanism of Prolactin-Releasing Peptide Recognition and Signaling via its G Protein-Coupled Receptor

Medicine, Endocrinology, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology, Biophysics,
prolactin-releasing peptide   G protein-coupled receptor   molecular mechanism   signaling   structural study  

Analysis of the Molecular Recognition and Signal Transduction Mechanism of PRRP and PRRPR Research Background Neuropeptides, as the most abundant signaling molecules in the nervous system, have over 100 identified types and play critical roles in processes like metabolism, pain sensation, and reproduction. Among them, RF-amide neuropeptides are cha...

Stem Cell Transplantation Extends the Reproductive Lifespan of Naturally Aging Cynomolgus Monkeys

Medicine, Obstetrics and Gynecology, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
stem cell transplantation   reproductive lifespan   ovarian aging   oxidative damage   cellular inflammation  

Stem Cell Transplantation Extends the Reproductive Lifespan of Naturally Aging Cynomolgus Monkeys Background of the Study The ovary is a crucial organ for female reproduction and health, responsible for producing oocytes and secreting sex hormones. As women age, ovarian reserves gradually decline, eventually leading to menopause, which brings about...

Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic B Cell Pyroptosis upon Viral Infection

Medicine, Infectious Diseases, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Immunology,
vascularized macrophage   islet organoids   B cell pyroptosis   viral infection   immune-mediated  

Background Since the outbreak of the COVID-19 pandemic, SARS-CoV-2 infection has not only affected the respiratory system but has also been closely related to metabolic diseases such as diabetes. Clinical observations have found occurrences of new-onset diabetes and worsening of existing diabetes among COVID-19 patients, particularly with an increa...