Ultrasound-Guided Mechanical High-Intensity Focused Ultrasound (Histotripsy) Through an Acoustically Permeable Polyolefin-Based Cranioplasty Device

Research Report: Feasibility Study of Intracranial Focused Ultrasound Ablation under Ultrasonic Guidance through Polyolefin-Based Cranial Implants Academic Background Histotripsy is a non-thermal, non-invasive cancer tumor ablation technology. When applied intracranially, it is limited by the skull’s significant absorption and reflection of ultraso...

Staged Bilateral MRI-Guided Focused Ultrasound Subthalamotomy for Parkinson Disease

MRI-Guided Staged Bilateral Focused Ultrasound Subthalamotomy for Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder, characterized mainly by motor symptoms such as tremor, rigidity, and bradykinesia. Traditionally, treatments for PD include medication and surgical interventions such as Deep Brain Stimula...

Intrathecal Bivalent CAR T Cells Targeting EGFR and IL13Rα2 in Recurrent Glioblastoma: Phase 1 Trial Interim Results

Intrathecal Bivalent CAR T Cells Targeting EGFR and IL13Rα2 in Recurrent Glioblastoma: Phase 1 Trial Interim Results

The Effectiveness of Bivalent CAR T-Cell Therapy Targeting EGFR and IL13Rα2 in Treating Recurrent Glioblastoma In recent years, the treatment of recurrent glioblastoma (RGBM) has been continually explored and improved, yet overall survival rates remain less than one year, presenting a significant challenge. The limitations of existing treatments an...

Information-Based TMS to Mid-Lateral Prefrontal Cortex Disrupts Action Goals During Emotional Processing

Abstract In recent years, researchers have gradually recognized that contextual awareness and goal-directed responses to emotional events are crucial for adaptive functioning. Behavioral and emotional regulation models posit that the lateral prefrontal cortex (lpfc) maintains goal-related representations, thereby facilitating cognitive control. How...

Connectome Reorganization Associated with Temporal Lobe Pathology and Its Surgical Resection

Connectome Reorganization Associated with Temporal Lobe Pathology and Its Surgical Resection

Connectomics Reconstruction Associated with Temporal Lobe Lesions and Their Surgical Resection Academic Background The human brain’s structural organization is increasingly conceptualized and analyzed from a network perspective, greatly enhancing understanding of health and disease. In recent years, thanks to advances in neuroimaging technology and...