Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Medicine, Rheumatology and Immunology, Nephrology, Gastroenterology, Life Sciences, Immunology,
T cells   plasticity   kidney inflammation   gut inflammation   single-cell CRISPR   autoimmune diseases  

Targeting T Cell Plasticity to Treat Inflammation in the Kidney and Gut: A Study Using Pooled Single-cell CRISPR Screening Background of the Study This paper, co-authored by Leon U.B. Enk and others, was published in the June 14, 2024, issue of “Science Immunology” under the title “Targeting T cell plasticity in kidney and gut inflammation by poole...

Gastrointestinal infections and gastrointestinal haemorrhage are underestimated but serious adverse events in chimeric antigen receptor T-cell recipients: a real-world study

Medicine, Infectious Diseases, Gastroenterology, Hematology, Oncology,
Chimeric antigen receptor   T-cell therapy   Gastrointestinal infections   Gastrointestinal haemorrhage   Multisystem toxicity   Adverse events   Real-world  

Gastrointestinal Infections and Gastrointestinal Bleeding in CAR-T Cell Recipients are Underrated but Severe Adverse Events: A Real-World Study Introduction In recent years, Chimeric Antigen Receptor T-cell (CAR-T) therapy has shown lasting efficacy in treating patients with hematologic malignancies. However, multi-system toxic reactions associated...

Enhanced Epithelial-Mesenchymal Transition Signatures Are Linked with Adverse Tumor Microenvironment, Angiogenesis, and Worse Survival in Gastric Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
epithelial-mesenchymal transition   gastric cancer   gene set variation analysis   survival rate   tumor microenvironment   angiogenesis  

Enhanced EMT Characteristics Associated with Unfavorable Tumor Microenvironment, Angiogenesis, and Poorer Prognosis in Gastric Cancer Academic Background Epithelial-Mesenchymal Transition (EMT) is an extremely important mechanism that promotes the metastasis of cancer cells. However, despite its apparent importance, the clinical significance of EMT...

Metagenomic Next-Generation Sequencing, instead of Procalcitonin, Could Guide Antibiotic Usage in Patients with Febrile Acute Necrotizing Pancreatitis: A Multicenter, Prospective Cohort Study

Medicine, Infectious Diseases, Medical Laboratory Science, Gastroenterology, Life Sciences, Microbiology,
acute necrotizing pancreatitis   antibiotic stewardship   infected pancreatic necrosis   metagenomic next-generation sequencing   procalcitonin  

Metagenomic Next-Generation Sequencing as an Alternative to Procalcitonin in Guiding Antibiotic Use in Patients with Acute Necrotizing Pancreatitis and Fever Background and Research Objectives Acute pancreatitis (AP) is one of the leading causes of emergency hospital admissions for digestive system diseases, with significant medical resource utiliz...

Watch-and-Wait Strategy vs. Resection in Patients with Radiologic Complete Response After Conversion Therapy for Initially Unresectable Hepatocellular Carcinoma: A Propensity Score-Matching Comparative Study

Medicine, Hepatobiliary System, Gastroenterology, Oncology,
complete response   conversion therapy   hepatocellular carcinoma   surgical resection   watch-and-wait strategy  

Observation vs Surgical Resection for Initial Unresectable Hepatocellular Carcinoma after Conversion Therapy Background Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and the third leading cause of cancer-related mortality. Partial hepatectomy can provide a 5-year survival rate of 70-80% in the treatment of early-stage HCC....