Targeted Nuclear Degranulation of Neutrophils Promotes the Progression of Pneumonia in Ulcerative Colitis

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophils   targeted nuclear degranulation   ulcerative colitis   pneumonia   immune cell migration  

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease often accompanied by various extraintestinal complications, among which pulmonary infections are particularly severe. Although previous studies have indicated interactions between the intestinal and pulmonary immune systems, the specific mechanisms involving neutrop...

Suppression of Myd88 Disturbs Gut Microbiota and Activates the NLR Pathway and Hence Fails to Ameliorate DSS-Induced Colitis

Medicine, Gastroenterology, Life Sciences, Immunology,
Myd88   gut microbiota   NLR pathway   colitis   inflammatory bowel disease  

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, primarily including Ulcerative Colitis (UC) and Crohn’s Disease (CD). In recent years, the incidence of IBD has been on the rise globally, placing a significant burden on healthcare systems. Although it is widely accepted that IBD is associ...

Impact of Postoperative Complications on Clinical Outcomes After Gastrectomy for Cancer: Multicentre Study

Medicine, Gastroenterology, Oncology,
gastric cancer   postoperative complications   multicentre study   clinical outcomes   anastomotic leakage   pulmonary complications   30-day mortality  

Gastric cancer is one of the most common malignant tumors worldwide, and surgical resection (gastrectomy) is the primary treatment. Although the application of minimally invasive techniques has reduced surgical trauma, the incidence of postoperative complications after gastrectomy remains high, ranging from 20% to 40%. These complications not only ...

Development and External Validation of Prediction Risk Scores (StrISK and NOFA) to Predict Immediate Surgical Need in Adhesive Small Bowel Obstruction: An Observational Prospective Multicentre Study

Medicine, Emergency Medicine, Gastroenterology,
Adhesive Small Bowel Obstruction   Prediction Model   Surgical Need   Multicentre Study   External Validation  

Background Introduction Adhesive Small Bowel Obstruction (ASBO) is one of the leading causes of emergency admissions, accounting for approximately 60% of all small bowel obstruction cases. ASBO is often caused by postoperative intra-abdominal adhesions, with patients presenting symptoms such as abdominal pain, vomiting, and constipation. While most...

Preoperative Stereotactic Radiotherapy to Prevent Pancreatic Fistula in High-Risk Patients Undergoing Pancreatoduodenectomy (FIBROPANC): Prospective Multicentre Phase II Single-Arm Trial

Medicine, Hepatobiliary System, Anesthesiology, Gastroenterology, Oncology,
pancreatic fistula   stereotactic radiotherapy   pancreatoduodenectomy   high-risk patients   fibrosis   safety   efficacy  

Pancreaticoduodenectomy is a common surgery for treating tumors of the pancreas and surrounding organs, but postoperative pancreatic fistula (POPF) is one of its major complications, especially in high-risk patients, where the incidence of POPF can be as high as 50%. POPF not only increases hospitalization time and medical costs but can also lead t...