Research and Development of a Novel PI3Kα Inhibitor: Molecular Hybridization Technology Leads to a Breakthrough in Lung Cancer Treatment Academic Background Cancer, particularly non-small cell lung cancer (NSCLC), is the second leading cause of death worldwide. Currently, chemotherapy is the primary treatment method, but due to its lack of targetin...

Targeted Drug Delivery Using Self-Unrolling Sheets in Magnetically Actuated Capsules Background Gastrointestinal (GI) diseases, such as inflammatory bowel disease, GI bleeding, and cancer, are significant global health issues. Traditional treatment methods, such as endoscopy and oral medications, though effective to some extent, have many limitatio...

A Novel Rectal Foam Formulation for the Treatment of Inflammatory Bowel Disease In recent years, the incidence of inflammatory bowel disease (IBD), characterized by mucosal damage, chronic inflammation, and recurrent episodes, has been steadily rising, yet ideal therapeutic solutions remain elusive. Researchers have identified a 33-amino acid pepti...

A Novel Study on Multifunctional Hydrogels for Promoting Infected Wound Healing In the current clinical setting, infected wounds, especially those caused by antibiotic-resistant pathogens, have become a major challenge. These chronic or hard-to-heal wounds often suffer from delayed healing processes due to excessive inflammation, bacterial biofilm ...

Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...

Breakthrough Research on Micro-Scale Exploration of Thrombolysis Kinetics Research Background and Problem Venous thromboembolism (VTE), a severe health condition, causes approximately 500,000 deaths annually in the United States alone. The occurrence of VTE is closely related to the formation and resistance to dissolution of thrombi in veins, commo...