Bioprinted Micro-Clots for Kinetic Analysis of Endothelial Cell-Mediated Fibrinolysis

Medicine, Medical Laboratory Science, Hematology, Pharmacy, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Biophysics,
bioprinting   micro-clots   fibrinolysis   endothelial cells   venous thromboembolism   drug testing   high-throughput analysis  

Breakthrough Research on Micro-Scale Exploration of Thrombolysis Kinetics Research Background and Problem Venous thromboembolism (VTE), a severe health condition, causes approximately 500,000 deaths annually in the United States alone. The occurrence of VTE is closely related to the formation and resistance to dissolution of thrombi in veins, commo...

Dual Ferroptosis Induction in N2-TANs and TNBC Cells via FTH1 Targeting: A Therapeutic Strategy for Triple-Negative Breast Cancer

Chemistry, Medicinal Chemistry, Medicine, Pharmacy, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
ferroptosis   triple-negative breast cancer   N2-TANs   FTH1   immune microenvironment   ferritinophagy   novel cancer therapy  

Dual Ferroptosis Induction via FTH1 Targeting: A New Therapeutic Strategy for Triple-Negative Breast Cancer (TNBC) Background: Why Conduct This Study? Breast cancer is one of the most common cancer types worldwide, accounting for 11.7% of all new cancer cases globally. Among its several subtypes, triple-negative breast cancer (TNBC) stands out for ...

Spatial Covariance Reveals Isothiocyanate Natural Products Adjust Redox Stress to Restore Function in Alpha-1-Antitrypsin Deficiency

Medicine, Hepatobiliary System, Respiratory System, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
spatial covariance   isothiocyanate   redox stress   alpha-1-antitrypsin deficiency   natural products   protein folding   nutraceuticals  

Potential Therapeutic Role of Dietary Isothiocyanate Compounds in Alpha-1 Antitrypsin Deficiency (AATD) Background and Significance of the Study Alpha-1 Antitrypsin Deficiency (AATD) is a congenital, monogenic disease primarily caused by the misfolding of alpha-1 antitrypsin (AAT) in the liver. This misfolding leads to two pathological effects: the...

The Direct and Indirect Inhibition of Proinflammatory Adipose Tissue Macrophages by Acarbose in Diet-Induced Obesity

Medicine, Rheumatology and Immunology, Endocrinology, Gastroenterology, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology,
Acarbose   Proinflammatory macrophages   Obesity   Gut microbiota   Immune regulation   Insulin resistance   Inflammation  

Exploring the Direct and Indirect Immunomodulatory Effects of Acarbose on Obesity-Associated Chronic Inflammation Academic Background With the global prevalence of obesity, related metabolic syndromes such as insulin resistance (IR), type 2 diabetes, cardiovascular diseases, and fatty liver disease have become major threats to human health. These c...

Overexpression of REF-1 in Neovascular Eye Diseases and Its Inhibition by a Novel Compound

Medicine, Ophthalmology, Pharmacy, Oncology, Life Sciences, Biochemistry,
REF-1   neovascularization   eye disease   inflammation   redox   macular degeneration   carbonic anhydrase  

REF-1 Overexpression in Neovascular Eye Diseases and Therapeutic Targeting with a Novel Inhibitor Academic Background Neovascular age-related macular degeneration (nAMD) is a common blinding eye disease predominantly affecting individuals aged 60 years and older. nAMD is characterized by the formation of subretinal neovascularization, leading to re...

Aztreonam-Avibactam: A New Combination with Activity Against Multidrug-Resistant Klebsiella pneumoniae Complex

Medicine, Infectious Diseases, Pharmacy, Life Sciences, Microbiology,
multidrug resistance   Klebsiella pneumoniae complex   Aztreonam-Avibactam   β-lactamase inhibitor   antibiotic resistance  

Aztreonam-Avibactam Activity Against Multidrug-Resistant Klebsiella pneumoniae Complex Background The Klebsiella pneumoniae complex (KPC) is a group of opportunistic pathogens that pose a serious threat to public health. In recent years, the infection rate of multidrug-resistant (MDR) Klebsiella pneumoniae has significantly increased, leading to ex...