The Landscape of Drug Sensitivity and Resistance in Sarcoma

Medicine, Basic Medical Sciences, Pharmacy, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
drug sensitivity   sarcoma   functional precision medicine   patient-derived tumor organoids   clinical correlation  

Background Introduction This study explores the landscape of individual drug sensitivity and resistance in sarcoma patients. Sarcomas are a diverse group of tumors originating from mesenchymal tissue, including types such as osteosarcoma and soft tissue sarcoma, mostly affecting young people. Although the annual incidence of sarcomas is relatively ...

Structural Basis of Psychedelic LSD Recognition at Dopamine D1 Receptor

Medicine, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Biophysics,
psychedelic   LSD   dopamine D1 receptor   structural biology   GPCR  

Structural Basis of LSD Recognition in Dopamine D1 Receptors Research Background and Problem Statement LSD (lysergic acid diethylamide) is a well-known hallucinogen that primarily exerts profound cognitive and perceptual effects by acting on various neurotransmitter receptors, including serotonin (5-HT) receptors and dopamine receptors. The 5-HT2A ...

Novel Insight into Atogepant Mechanisms of Action in Migraine Prevention

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Pharmacy, Life Sciences, Cell Biology,
migraine   headache   trigeminovascular   gepants   central sensitization   pain  

New Research Reveals the Mechanism of Atogepant in Migraine Prevention Background Migraine is a common and highly disruptive neurological disorder affecting millions of people worldwide. Calcitonin Gene-Related Peptide (CGRP) is believed to play a key role in the pathophysiology of migraine. CGRP released from sensory trigeminal ganglia neurons in ...

Targeting the Transferrin Receptor to Transport Antisense Oligonucleotides Across the Mammalian Blood-Brain Barrier

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology,
transferrin receptor   antisense oligonucleotides   blood-brain barrier   central nervous system   drug delivery  

Introduction In recent years, oligonucleotide-based therapeutic technologies, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have been widely applied in the treatment of various neurological disorders. The basis for their application is that these technologies can selectively regulate target RNA molecules, which are ...

Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice

Chemistry, Medicinal Chemistry, Medicine, Neurology, Pharmacy, Life Sciences, Biochemistry,
hearing loss   aminoglycosides   TRPV1   mouse model   protective mechanism  

Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice Academic Background Hearing loss is a serious global health problem affecting over 400 million people worldwide, according to the World Health Organization. Aminoglycoside antibiotics, while widely used in medicine due to their broad-spectrum antibact...

Public Views on Whether the Use of Pharmaceutical Neuroenhancements Should Be Allowed

Medicine, Environmental and Public Health, Neurology, Pharmacy,
pharmaceutical neuroenhancements   public views   regulation   societal effects   individual effects  

Research Report on Whether the Public Should Be Allowed to Use Drug Enhancers Introduction In recent years, some individuals have started using drugs to enhance cognitive and socio-emotional functions and have requested off-label prescriptions from doctors for neuroenhancement (e.g., stimulants). However, discussions about whether such uses should ...