Transcriptionally Downregulated GABAergic Genes Associated with Synaptic Density Network Dysfunction in Temporal Lobe Epilepsy

Medicine, Neurology, Medical Imaging, Life Sciences, Biochemistry, Genetics,
Temporal Lobe Epilepsy   Synaptic Density Network   SV2A PET   Gene Expression   GABAergic Inhibition  

Revealing Gene Expression Patterns Associated with Synaptic Density Network Dysfunction in Temporal Lobe Epilepsy Background Temporal Lobe Epilepsy (TLE) is the most common form of focal epilepsy, and its pathological features and mechanisms have long drawn extensive attention in the field of neuroscience. This disorder involves not only a single b...

Impact of FAPI Molar Dose on Targeted PET Imaging and Therapy in Mouse Syngeneic Tumor Models

Medicine, Medical Imaging, Oncology,
Molar dose   Targeted imaging   Mouse models   Radiotherapy   FAPI   Cancer-associated fibroblasts   Preclinical research  

Background In recent years, significant progress has been made in the field of cancer diagnosis and treatment, particularly in technologies based on molecular imaging and targeted radiotherapy. Among these, Fibroblast Activation Protein (FAP), a biomarker highly expressed in the tumor microenvironment, has garnered widespread attention. FAP is prim...

Clinical impact of an explainable radiomics model with amino acid PET imaging: application to the diagnosis of aggressive gliomas

Information Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging, Oncology,
explainable radiomics   amino acid PET   aggressive gliomas   radiologic diagnostics   model-supported interpretation  

Application of Explainable Machine Learning in Amino Acid PET Imaging for Glioma Diagnosis Academic Background Gliomas are among the most common malignant tumors of the central nervous system, with their diagnosis and treatment strategies typically relying on histopathological analysis. However, histopathology has limitations such as being highly i...

Ultra-Fast PSMA-PET Staging in Prostate Cancer Enhanced by Artificial Intelligence

Information Science, Artificial Intelligence, Medicine, Urology, Medical Imaging, Oncology,
prostate cancer   artificial intelligence   PSMA-PET   ultra-fast imaging   image quality   tumor staging   nuclear medicine  

Application of AI-Enhanced Ultra-Fast PSMA-PET in Prostate Cancer Staging Academic Background Prostate cancer is one of the most common cancers among men globally, and accurate diagnosis and staging are crucial for treatment decision-making. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has become a standard examinati...

Early-phase Tau-PET as a proxy of brain metabolism in Alzheimer’s disease: a comparison with 18F-FDG-PET and early-phase Amyloid-PET

Medicine, Neurology, Medical Imaging,
Neurodegeneration   Early-phase Tau-PET   18F-FDG-PET   Brain perfusion   18F-Flortaucipir  

Early-phase 18F-Flortaucipir Tau-PET as a Proxy for Brain Metabolism in Alzheimer’s Disease Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by extracellular β-amyloid (Aβ) deposition, intracellular pathological tau protein accumulation, and neurodegeneration. These pathological changes begin accumulating in ...