Multi-omics-based Mapping of Decidualization Resistance in Patients with a History of Severe Preeclampsia

Multi-omics technology reveals the mechanism of endometrial decidualization resistance in patients with severe preeclampsia Academic background Preeclampsia (PE) is a common and serious complication during pregnancy, primarily characterized by hypertension, proteinuria, and dysfunction of other organs, posing a significant threat to maternal and fe...

Reduced-Energy Diet in Women with Gestational Diabetes: The Dietary Intervention in Gestational Diabetes DIGEST Randomized Clinical Trial

Research Report on Low-Energy Diet Intervention in Gestational Diabetes Academic Background Gestational Diabetes Mellitus (GDM) is a form of diabetes diagnosed for the first time during pregnancy, with a global incidence rate of approximately 6-15%. GDM not only increases the risk of short-term complications for both mothers and fetuses, such as la...

Automation and Control of Embryo Trophectoderm Cell Biopsy at the Blastocyst Stage

Application of Automation Technology in Embryo Trophectoderm Cell Biopsy Academic Background Embryo biopsy is a crucial step in assisted reproductive technology (In Vitro Fertilization, IVF), especially in Preimplantation Genetic Testing (PGT). Through embryo biopsy, doctors can extract a small number of cells from embryos for genetic analysis to a...

p300 maintains primordial follicle activation by repressing VEGFA transcription

Mechanism Study of p300 Maintaining Primordial Follicle Activation by Inhibiting VEGFA Transcription Academic Background In the female reproductive system, primordial follicles (PFs) are the earliest formed follicles in the ovary, remaining dormant and awaiting activation to enter the growth phase. The activation of primordial follicles is a key fa...

Histone Lactylation-Mediated Overexpression of RASD2 Promotes Endometriosis Progression via Upregulating the SUMOylation of CTPS1

Histone Lactylation Promotes Endometriosis Progression by Upregulating CTPS1 SUMOylation Academic Background Endometriosis is a common reproductive endocrine disease affecting approximately 10% of women of reproductive age worldwide. Its main symptoms include dysmenorrhea, chronic pelvic pain, infertility, and menstrual abnormalities. Although the ...