Trend Change Analysis of Postural Balance in Parkinson’s Disease Discriminates Between Medication State

Analysis of Trend Changes in Static Balance of Parkinson’s Disease Patients to Distinguish Drug States Introduction Maintaining static body balance is crucial for daily living, which requires coordination between different body segments. Any change or decline in balance ability increases the risk of falling. Patients with Parkinson’s disease (PD) e...

Time Synchronization Between Parietal–Frontocentral Connectivity with MRCP and Gait in Post-Stroke Bipedal Tasks

Time Synchronization of Motor-Related Cortical Potentials and Parieto-Frontocentral Connectivity in Bilateral Tasks of Stroke Patients Background In stroke rehabilitation research, functional connectivity (FC), motor-related cortical potentials (MRCP), and gait activities are common metrics related to rehabilitation outcomes. Although these have be...

Study on the Effects of Traumatic Brain Injury on Chronic Meningeal CLIP+ B Cells, Neuropathology, and Neurobehavioral Impairment in 5xFAD Mice

Research Report: Long-Term Effects of Class II Invariant Peptide (CLIP) Antagonism on CLIP+ B Cells in the Meninges, Neuropathology, and Neurobehavioral Deficits in 5xFAD Mice Research Background Traumatic brain injury (TBI) is a significant public health problem affecting millions of individuals worldwide each year. More importantly, TBI is a sign...

Changes in Growth-Associated Protein 43 and Tensor-Based Morphometry Indices in Mild Cognitive Impairment

Changes in Growth-Associated Protein 43 and Tensor-Based Morphometric Indicators in Mild Cognitive Impairment Research Background Alzheimer’s disease (AD) is a globally prevalent neurodegenerative disease whose incidence is expected to increase significantly in the coming years (Esquerda-Canals et al., 2017). The disease primarily manifests as defe...

Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease

Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease

Co-localization of Gangliosides with Amyloid Beta Plaques in Alzheimer’s Disease Detected by MALDI-MSI and Histology Alzheimer’s Disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment and behavioral changes. Historically, AD research has focused on misfolded proteins, but with advancements in mass spectrometry...