Cardiovascular Disease and Breast Cancer Stage at Diagnosis

Medicine, Oncology, Cardiovascular System,
cardiovascular disease   breast cancer   diagnosis stage   case-control study   risk factors   hormone receptor-positive   personalized screening  

Association Between Cardiovascular Disease and Breast Cancer Stage at Diagnosis Academic Background Cardiovascular disease (CVD) and cancer are the two leading causes of mortality in the United States. Although they share many common risk factors, recent studies suggest that CVD may directly promote the occurrence and progression of cancer. Specifi...

Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators with Putative Liver Roles

Medicine, Hepatobiliary System, Hematology, Cardiovascular System, Life Sciences, Genetics,
plasma fibrinogen   whole-genome analysis   genetic regulation   population differentiation   liver roles   genetic variation   biomarkers  

Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators with Potential Liver Roles Academic Background Fibrinogen is a crucial coagulation factor and acute-phase reactive protein. Under normal physiological conditions, fibrinogen is abundant in circulation, but during the acute inflammatory response, transcri...

Neuropilin-1 Controls Vascular Permeability through Juxtacrine Regulation of Endothelial Adherens Junctions

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
Neuropilin-1   vascular permeability   signalling   VE-cadherin   VEGFA  

Neuropilin-1 (Nrp1) is a multifunctional transmembrane protein that is abundantly expressed on the surface of various cell types, where it binds to class 3 semaphorins (Sema3), heparan sulfate, and vascular endothelial growth factors (VEGFs). Nrp1 plays a crucial role in angiogenesis and vascular permeability regulation, particularly in the VEGF si...

ALK1/Endoglin Signaling Restricts Vein Cell Size Increases in Response to Hemodynamic Cues

Medicine, Cardiovascular System, Life Sciences, Cell Biology,
ALK1   Endoglin   hemodynamic cues   vein cells   arteriovenous malformations   zebrafish   hereditary hemorrhagic telangiectasia  

ALK1/Endoglin Signaling Restricts Vein Cell Size Increases in Response to Hemodynamic Cues Academic Background The normal development and function of the vascular system rely on precise regulation of blood vessel diameter. Hemodynamic cues, such as fluid shear stress (FSS), are considered critical factors in regulating vessel diameter. According to...

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice

Medicine, Cardiovascular System,
aortic aneurysm   endothelial cells   heterogeneity   site-specificity   RNA-seq  

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice Academic Background Aortic aneurysm (AA) is characterized by pathological dilation at specific predilection sites of the vessel, potentially leading to life-threatening vascular rupture. Aortic aneurysms typic...

Oscillatory Contractile Forces Refine Endothelial Cell-Cell Interactions for Continuous Lumen Formation Governed by Heg1/CCM1

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biophysics,
oscillatory contractile forces   endothelial cells   Heg1   CCM1   lumen formation   cell-cell interactions   angiogenesis  

Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...