Recombinant vs Egg-Based Quadrivalent Influenza Vaccination for Nursing Home Residents: A Cluster Randomized Trial

Medicine, Infectious Diseases, Geriatrics,
influenza vaccine   nursing home   randomized trial   recombinant vaccine   egg-based vaccine   hospitalization rates   COVID-19  

Comparative Analysis of Recombinant Quadrivalent Influenza Vaccine and Standard Egg-Based Quadrivalent Influenza Vaccine in Nursing Home Residents: A Cluster Randomized Trial Academic Background Influenza is among the primary respiratory pathogens causing morbidity and mortality among the elderly worldwide, particularly in nursing home residents wh...

Glutamatergic Medications for Obsessive-Compulsive and Related Disorders: A Systematic Review and Meta-Analysis

Medicine, Psychiatry,
glutamatergic medications   obsessive-compulsive disorder   meta-analysis   randomized controlled trials   neuropsychiatric disorders   treatment efficacy   subgroup analysis  

A Systematic Review and Meta-Analysis of Glutamatergic Medications for Obsessive-Compulsive and Related Disorders (OCRDs) Academic Context Obsessive-Compulsive and Related Disorders (OCRDs) represent a group of neuropsychiatric conditions characterized by excessive, persistent obsessions or compulsions. These disorders include Obsessive-Compulsive ...

Parent-Targeted Oral Health Text Messaging for Underserved Children Attending Pediatric Clinics: A Randomized Clinical Trial

Medicine, Pediatrics, Oral Sciences,
oral health   text messaging   randomized clinical trial   low-income families   childhood caries   preventive dental behaviors   health disparities  

Academic Paper Report Caries is one of the most common chronic diseases in children, with significant health disparities across racial, ethnic, and income groups. Despite the availability of effective preventive measures, children from low-income and minority ethnic groups continue to face higher risks of caries. The American Academy of Pediatrics ...

Cost-Effectiveness of Breast Cancer Screening Using Digital Mammography in Canada

Medicine, Oncology,
breast cancer screening   cost-effectiveness analysis   digital mammography   Canada   public health policy  

Economic Evaluation of Breast Cancer Screening: A Study Based on Digital Mammography in Canada Academic Background Breast cancer (BC) is one of the most commonly diagnosed cancers in women and the second leading cause of cancer-related deaths in North America. Although significant progress has been made in breast cancer treatment over the past deca...

Association of CHEK2 Low-Risk Variants with Cancer Phenotypes

Medicine, Oncology, Life Sciences, Genetics,
CHEK2   low-risk variants   cancer phenotypes   breast cancer   genetic modifiers  

Association of CHEK2 Low-Risk Variants with Cancer Phenotypes Academic Background The CHEK2 gene (OMIM 604373) is one of the susceptibility genes for breast cancer. Monoallelic pathogenic variants (PVs) in CHEK2 are associated with an increased risk of breast, colorectal, kidney, and thyroid cancers. However, there is limited research on the phenot...

Tissue Plasminogen Activator or Perfluoropropane for Submacular Hemorrhage in Age-Related Macular Degeneration: A Factorial Randomized Clinical Trial

Medicine, Ophthalmology,
submacular hemorrhage   age-related macular degeneration   tissue plasminogen activator   perfluoropropane   randomized clinical trial   visual acuity improvement   anti-VEGF therapy  

Academic Context and Problem Statement Age-related macular degeneration (AMD) is one of the leading causes of vision loss in many high-income countries. Among its forms, neovascular AMD (also known as wet AMD) can be associated with submacular hemorrhage (SMH), a rare but severe condition. If untreated, SMH can lead to significant vision loss. Anti...