Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
oocyte   granulosa cell   transcriptome   folliculogenesis   cell dialog  

Transcriptome Dynamics and Cell Dialogue Between Oocytes and Granulosa Cells During Mouse Follicle Development Overview Follicle development and maturation is a complex, multi-stage process. During this process, dynamic gene expression in oocytes and surrounding somatic cells, as well as the dialogue between them, play crucial roles. This study rev...

A novel protein cytb-187aa encoded by the mitochondrial gene cytb modulates mammalian early development

Medicine, Obstetrics and Gynecology, Life Sciences, Cell Biology, Biochemistry, Genetics,
mitochondria   cytb-187aa   early development   ATP production   pluripotent state   ovarian follicles   female fertility  

The New Protein Cytb-187aa Regulates Mammalian Early Development Academic Background Mitochondria are multifunctional organelles that provide energy for cells. In addition to energy supply, they are involved in the regulation of apoptosis, cell signaling, and various biosynthetic pathways. Among these functions, substances within mitochondria can b...

Fetal Brain MRI Abnormalities in Pyruvate Dehydrogenase Complex Deficiency

Medicine, Pediatrics, Obstetrics and Gynecology, Neurology, Medical Imaging,
Pyruvate Dehydrogenase   Complex Deficiency   Fetal MRI   Brain Abnormalities   Genetic Disorder   Second Trimester Diagnosis  

Abnormalities in Fetal Brain MRI in Pyruvate Dehydrogenase Complex Deficiency Background and Research Objective Pyruvate Dehydrogenase Complex Deficiency (PDCD) is a mitochondrial metabolic disorder caused by pathogenic variants in multiple genes, including PDHA1. Classic neonatal brain imaging features have been described, mainly focusing on devel...

Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age from Blind Ultrasound Sweeps

Information Science, Artificial Intelligence, Medicine, Obstetrics and Gynecology, Medical Imaging,
integrated AI tool   gestational age estimation   diagnostic accuracy   blind ultrasound sweeps   low-resource settings   pregnancy care   obstetrical sonography  

Diagnostic Accuracy of AI Tools for Estimating Gestational Age Based on Blind Ultrasound Scanning Background Accurate estimation of gestational age (GA) is the foundation of good prenatal care, typically achieved through ultrasound examinations. However, many low-resource areas lack sufficient ultrasound equipment, making accurate GA estimation cha...

Genome, HLA and Polygenic Risk Score Analyses for Prevalent and Persistent Cervical Human Papillomavirus (HPV) Infections

Medicine, Infectious Diseases, Obstetrics and Gynecology, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
Genome   HLA   Polygenic Risk Score   Cervical HPV   Persistent Infection  

Genome-wide and Polygenic Risk Score Analysis of High-Risk Human Papillomavirus (hrHPV) Infection in the Cervix Background Cervical high-risk human papillomavirus (hrHPV) infection is the second largest carcinogenic infection globally, accounting for approximately 31.4% of all infection-related cancers (about 690,000 cases out of 2.2 million cancer...