The Role of Sirtuins in Obesity and Osteoporosis and Their Therapeutic Potential Academic Background Obesity and osteoporosis (OP) are increasingly severe public health issues worldwide. Obesity is not only closely related to metabolic diseases such as cardiovascular diseases and diabetes but also has a complex association with the occurrence of os...

Novel Germline Mutations in FUT7 and EXT1 Linked to Hereditary Multiple Exostoses Background Hereditary Multiple Exostoses (HME), also known as Hereditary Multiple Osteochondromas (HMO), is an autosomal dominant skeletal disorder characterized by the development of multiple cartilage-capped bone projections (osteochondromas). These osteochondromas ...

Academic Research Report: MCL1 Copy Number Gain as a Therapeutic Target for Osteosarcoma Academic Background Osteosarcoma (OS) is a primary malignant bone tumor that predominantly affects children and adolescents. Although the treatment regimen combining surgery with chemotherapy was established in the 1970s and remains the standard therapy, progre...

Osteochondral Abnormalities on Three-Dimensional Ultrashort Echo Time MRI Scans Are Associated with Knee Cartilage Degradation Academic Background Osteoarthritis (OA) is the most prevalent musculoskeletal disease, characterized by pain and disability. A hallmark of OA is the progressive loss of articular hyaline cartilage, which connects to the sub...

The Role of Gut Microbial Changes in Lysine Metabolism on Bone Mechanical Adaptation Research Background Osteoporosis, a severe global public health issue, affects over 200 million people, posing significant threats to health and life. Studies have shown that maintaining bone health and preventing osteoporosis are closely linked to mechanical load....