A Two-Phase Epigenome-Wide Four-Way Gene–Smoking Interaction Study of Overall Survival for Early-Stage Non-Small Cell Lung Cancer

Medicine, Respiratory System, Oncology,
epigenomics   four-way interaction   gene–smoking interaction   non-small cell lung cancer   survival analysis   DNA methylation   molecular mechanisms  

Study on the Four-Way Gene-Smoking Interaction and Survival in Early-Stage Non-Small Cell Lung Cancer Research Background Lung cancer is one of the most prevalent malignancies worldwide and a leading cause of cancer-related mortality. According to global cancer statistics, approximately 2.5 million new cases are diagnosed annually, with 1.8 million...

Senescent Lung Fibroblasts in Idiopathic Pulmonary Fibrosis Facilitate Non-Small Cell Lung Cancer Progression by Secreting Exosomal MMP1

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Immunology,
Idiopathic Pulmonary Fibrosis   Non-Small Cell Lung Cancer   Exosomes   MMP1   PI3K-AKT-mTOR Pathway   Senescence-Associated Secretory Phenotype   Tumor Microenvironment  

Academic Background and Problem Statement Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease associated with aging and is an independent risk factor for lung cancer. Epidemiological studies indicate that 3%-22% of IPF patients develop lung cancer during follow-up, with the cumulative incidence increasing over time, makin...

TFF3 Drives Hippo-Dependent EGFR-TKI Resistance in Lung Adenocarcinoma

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Immunology,
Lung Adenocarcinoma   EGFR-TKI Resistance   TFF3   Hippo Signaling Pathway   YAP Protein   Molecular Targeted Therapy   Cancer Resistance Mechanisms  

TFF3 Drives Hippo-Dependent EGFR-TKI Resistance in Lung Adenocarcinoma Academic Background Lung adenocarcinoma (LUAD) is one of the most common subtypes of non-small cell lung cancer (NSCLC), with frequent mutations in the epidermal growth factor receptor (EGFR). Since 2013, EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib, erlotinib, and o...

A Wearable Echomyography System Based on a Single Transducer

Engineering, Electrical Engineering, Information Science, Artificial Intelligence, Medicine, Respiratory System, Neurology, Medical Imaging, Life Sciences, Bioengineering,
wearable devices   echomyography   single transducer   deep learning   muscle activity monitoring   wireless circuit   ultrasound  

Innovative Advances in Wearable Single-Transducer Echomyography Systems: From Muscle Dynamics Monitoring to Complex Gesture Tracking Academic Background and Research Significance In recent years, wearable electronic devices have garnered significant attention for their enormous potential in health monitoring and human-machine interaction. Electromy...

Factors in Initial Anticoagulation Choice in Hospitalized Patients with Pulmonary Embolism

Medicine, Respiratory System, Emergency Medicine, Cardiovascular System,
pulmonary embolism   anticoagulation   hospitalized patients   guideline adherence   heparin   low-molecular-weight heparin   treatment choice  

Pulmonary Embolism (PE) Overview Pulmonary Embolism (PE) is a serious medical emergency with an annual incidence of approximately 60 to 120 cases per 100,000 people in North America and Europe. Most patients are diagnosed with PE in the Emergency Department (ED), and hospitalization is required for the majority of U.S. patients. Anticoagulation is ...

Assessing Lung Ventilation and Bronchodilator Response in Asthma and Chronic Obstructive Pulmonary Disease with 19F MRI

Medicine, Respiratory System, Medical Imaging,
19F MRI   lung ventilation   bronchodilator response   asthma   chronic obstructive pulmonary disease  

Academic Background and Problem Statement Respiratory diseases impose a significant burden on healthcare systems globally. Although existing pulmonary function tests (such as conventional spirometry) aid in disease diagnosis and monitoring, these methods are relatively insensitive in detecting early-stage diseases and cannot provide information on ...