Organ-Specific Microenvironments Drive Divergent T Cell Evolution in Acute Graft-Versus-Host Disease

Medicine, Rheumatology and Immunology, Hepatobiliary System, Respiratory System, Gastroenterology, Hematology, Life Sciences, Immunology,
Graft-versus-host disease   T cell evolution   Organ microenvironment   Immunopathology   Single-cell RNA sequencing  

Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...

Ciliopathies: Undocking of an Extensive Ciliary Network Induces Proteostasis and Cell Fate Switching Resulting in Severe Primary Ciliary Dyskinesia

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Genetics,
Primary Ciliary Dyskinesia   Ciliary Network   Proteostasis   Cell Fate Switching   Gene Therapy  

Research on Ciliary Diseases: The Role of CCDC39/CCDC40 Heterodimer in Primary Ciliary Dyskinesia Academic Background Primary Ciliary Dyskinesia (PCD) is a rare monogenic disorder characterized by chronic respiratory infections, infertility, and organ laterality defects. Although more than 50 genes associated with PCD have been identified, mutation...

Perinatal Dysfunction of Innate Immunity in Cystic Fibrosis

Medicine, Infectious Diseases, Pediatrics, Rheumatology and Immunology, Respiratory System, Life Sciences, Immunology,
Cystic Fibrosis   Innate Immunity   Perinatal   Lung Damage   Inflammation   Monocytes   Transcriptomic Profiling  

Study on Congenital Immune Dysfunction in Cystic Fibrosis Research Background Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, primarily affecting the lungs and digestive system. One of the major problems faced by CF patients is recurrent infections and inflammatio...

Mechanism of GADD45B-Mediated Inflammation and Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease

Medicine, Respiratory System, Life Sciences,
Chronic Obstructive Pulmonary Disease   Inflammation   Cellular Senescence   DNA Methylation   GADD45B   p38 Phosphorylation   Cigarette Smoke  

DNA Hypomethylation-Mediated Upregulation of GADD45B Facilitates Airway Inflammation and Epithelial Cell Senescence in COPD Academic Background Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease characterized by chronic airway inflammation and irreversible airflow limitation, and it is one of the leading causes of death worldwi...

Ultralow-Power Carbon Dioxide Sensor for Real-Time Breath Monitoring

Chemistry, Nanoscience, Engineering, Electrical Engineering, Materials Science, Medicine, Respiratory System, Life Sciences, Bioengineering,
carbon dioxide sensor   breath monitoring   optochemical sensor   low power consumption   real-time monitoring  

Research on an Ultra-Low Power Carbon Dioxide Sensor for Real-Time Breath Monitoring Academic Background Carbon dioxide (CO₂) is a critical gas produced during human respiration, and its real-time monitoring is essential for diagnosing and treating respiratory diseases (e.g., asthma, dyspnea, sleep apnea) as well as metabolic disorders. Traditional...

A Potential 3-in-1 Combined Anti-SARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Infectious Diseases, Respiratory System, Pharmacy, Life Sciences, Biochemistry, Immunology,
COVID-19   metal-organic frameworks   antiviral therapy   pulmonary treatment   Favipiravir   heparin   drug delivery  

Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...