Nerve- and Airway-Associated Interstitial Macrophages Mitigate SARS-CoV-2 Pathogenesis via Type I Interferon Signaling

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Immunology,
SARS-CoV-2   Type I Interferon   Macrophages   Inflammation   Viral Infection  

1. Academic Background The COVID-19 pandemic has highlighted the importance of immunoregulatory mechanisms in respiratory viral infections. Despite vaccine advancements, the rapid mutation of SARS-CoV-2 continues to threaten public health. Studies indicate that severe COVID-19 cases are often associated with dysregulated immune responses rather tha...

IL-10 Sensing by Lung Interstitial Macrophages Prevents Bacterial Dysbiosis-Driven Pulmonary Inflammation and Maintains Immune Homeostasis

Medicine, Rheumatology and Immunology, Respiratory System, Life Sciences, Cell Biology, Immunology, Microbiology,
IL-10   Lung Interstitial Macrophages   Bacterial Dysbiosis   Pulmonary Inflammation   Immune Homeostasis   Chronic Inflammation   Microbiota  

1. Research Background The pathogenesis of chronic lung inflammation and pulmonary fibrosis remains unclear, particularly regarding the interaction between pulmonary commensal microbiota and the immune system. While interleukin-10 (IL-10), a key anti-inflammatory cytokine, has been extensively studied in gut homeostasis, its role in pulmonary immun...

Management of High-Risk Acute Pulmonary Embolism: An Emulated Target Trial Analysis

Medicine, Respiratory System, Emergency Medicine, Cardiovascular System,
High-risk pulmonary embolism   Systemic thrombolysis   Surgical thrombectomy   Percutaneous catheter-directed treatment   Mechanical circulatory support  

Target Trial Emulation Analysis for the Management of High-Risk Acute Pulmonary Embolism Background Introduction Acute pulmonary embolism (PE) is a life-threatening cardiovascular disease affecting more than 35 people per 100,000 annually. Approximately 5% of PE patients present with persistent hypotension, cardiogenic shock, or cardiac arrest, oft...

Effectiveness of Bundle of Care on Tolerance of Awake-Prone Positioning in Patients with Acute Respiratory Failure: A Multicenter Observational Study

Medicine, Nursing, Respiratory System,
acute respiratory failure   awake-prone positioning   multicenter study   bundle of care   high-flow nasal oxygen  

Effectiveness Study of Awake Prone Positioning Care Strategies in Patients with COVID-19 Related Acute Respiratory Failure Background Introduction During the COVID-19 pandemic, acute respiratory failure (Acute Respiratory Failure, ARF) became one of the main complications in critically ill patients. For patients requiring high-flow nasal oxygen (Hi...

A Quantitative Comparison of Electrode Positions for Respiratory Surface EMG

Medicine, Respiratory System, Neurology, Life Sciences, Bioengineering,
respiratory surface EMG   electrode positioning   quantitative comparison   clinical research   standardization  

A Quantitative Comparison Study of Electrode Positions for Respiratory Surface Electromyography Academic Background Respiratory surface electromyography (SEMG) is a non-invasive technique used to record the electrical activity of respiratory muscles. It is widely applied in analyzing respiratory effort, patient-ventilator asynchrony, and respirator...

Organ-Specific Microenvironments Drive Divergent T Cell Evolution in Acute Graft-Versus-Host Disease

Medicine, Rheumatology and Immunology, Hepatobiliary System, Respiratory System, Gastroenterology, Hematology, Life Sciences, Immunology,
Graft-versus-host disease   T cell evolution   Organ microenvironment   Immunopathology   Single-cell RNA sequencing  

Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...