Assessing Lung Ventilation and Bronchodilator Response in Asthma and Chronic Obstructive Pulmonary Disease with 19F MRI

Medicine, Respiratory System, Medical Imaging,
19F MRI   lung ventilation   bronchodilator response   asthma   chronic obstructive pulmonary disease  

Academic Background and Problem Statement Respiratory diseases impose a significant burden on healthcare systems globally. Although existing pulmonary function tests (such as conventional spirometry) aid in disease diagnosis and monitoring, these methods are relatively insensitive in detecting early-stage diseases and cannot provide information on ...

Low-Dose CT Screening in East Asian Women Who Have Never Smoked: Association Between Family History of Lung Cancer and Ground-Glass Nodule Prevalence and Growth

Medicine, Respiratory System, Medical Imaging, Oncology,
Low-dose CT screening   Ground-glass nodules   Family history of lung cancer   Asian women   Lung cancer risk  

Low-Dose CT Screening in East Asian Women Who Have Never Smoked: Association Between Family History of Lung Cancer and Ground-Glass Nodule Prevalence and Growth Academic Background Lung cancer is the leading cause of cancer-related mortality worldwide, and smoking is a well-established risk factor for lung cancer. Low-dose CT (LDCT) is an effective...

The Respiratory Microbiome is Linked to the Severity of RSV Infections and the Persistence of Symptoms in Children

Medicine, Infectious Diseases, Pediatrics, Respiratory System, Life Sciences, Microbiology,
respiratory microbiome   RSV infection   symptom persistence   child health   microbial community  

The Respiratory Microbiome is Linked to the Severity of RSV Infections and the Persistence of Symptoms in Children Academic Background Respiratory Syncytial Virus (RSV) is a leading cause of respiratory infections and hospitalizations in infants. While known risk factors for severe infections include preterm birth, congenital heart disease, and bro...

The Role of Radioresistant-Related Telomere Genes in the Prognosis and Immune Infiltration of Lung Adenocarcinoma

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
lung adenocarcinoma   radiotherapy   telomere genes   immune infiltration   prognostic model  

The Impact of Radioresistant-Related Telomere Genes on Prognosis and Immune Infiltration in Lung Adenocarcinoma Lung adenocarcinoma (LUAD), a common subtype of non-small cell lung cancer (NSCLC), has a high incidence and mortality rate. Despite significant progress in early detection and treatment, the overall survival (OS) rate of LUAD patients re...

Alveolar Regeneration by Airway Secretory-Cell-Derived p63+ Progenitors

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Genetics,
alveolar regeneration   airway secretory cells   p63+ progenitors   genetic lineage tracing   lung injury  

Alveolar Regeneration: Role of p63+ Progenitor Cells Derived from Airway Secretory Cells Background Introduction Effective gas exchange in the lungs relies on the precise structure and function of various epithelial cells, distributed across two distinct structural regions: ductal airways and alveoli. When alveoli are damaged (e.g., due to inhaled ...

Sustained Amphiregulin Expression in Intermediate Alveolar Stem Cells Drives Progressive Fibrosis

Medicine, Respiratory System, Life Sciences, Biochemistry, Immunology,
alveolar stem cells   Amphiregulin   fibrosis   IPF   disease severity   neutralizing antibody  

Persistent Expression of Amphiregulin (AREG) in Intermediate Alveolar Stem Cells Drives Progressive Pulmonary Fibrosis Background Fibrotic diseases are a leading cause of up to 45% of deaths in developed countries. Pulmonary fibrosis is a disease characterized by alveolar structure damage and impaired gas exchange, with Idiopathic Pulmonary Fibrosi...