A Potential 3-in-1 Combined Anti-SARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Infectious Diseases, Respiratory System, Pharmacy, Life Sciences, Biochemistry, Immunology,
COVID-19   metal-organic frameworks   antiviral therapy   pulmonary treatment   Favipiravir   heparin   drug delivery  

Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...

Spatial Covariance Reveals Isothiocyanate Natural Products Adjust Redox Stress to Restore Function in Alpha-1-Antitrypsin Deficiency

Medicine, Hepatobiliary System, Respiratory System, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
spatial covariance   isothiocyanate   redox stress   alpha-1-antitrypsin deficiency   natural products   protein folding   nutraceuticals  

Potential Therapeutic Role of Dietary Isothiocyanate Compounds in Alpha-1 Antitrypsin Deficiency (AATD) Background and Significance of the Study Alpha-1 Antitrypsin Deficiency (AATD) is a congenital, monogenic disease primarily caused by the misfolding of alpha-1 antitrypsin (AAT) in the liver. This misfolding leads to two pathological effects: the...

Estimation of Heart Rate and Respiratory Rate by Fore-Background Spatiotemporal Modeling of Videos

Information Science, Artificial Intelligence, Medicine, Respiratory System, Medical Imaging, Life Sciences, Bioengineering,
Heart Rate Estimation   Respiratory Rate Estimation   Video Analysis   Fore-Background Modeling   Spatiotemporal Maps   Lightweight Network   Non-Intrusive Measurement  

A New Method for Estimating Heart Rate and Respiratory Rate from Videos Background and Research Motivation Heart rate (HR) and respiratory rate (RR) are critical physiological parameters reflecting cardiorespiratory functions. These metrics are widely used in medical, health monitoring, and psychological and behavioral studies. Traditionally, these...

Multisite DNA Methylation Alterations of Peripheral Blood Mononuclear Cells Serve as Novel Biomarkers for the Diagnosis of AIS/Stage I Lung Adenocarcinoma: A Multicenter Cohort Study

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
DNA methylation   early detection   lung adenocarcinoma   peripheral blood mononuclear cells   biomarkers   multicenter study   epigenetics  

Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...

Circulating Extracellular Vesicles as Promising Biomarkers for Precision Diagnostics: A Perspective on Lung Cancer

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Bioengineering, Immunology, Genetics, Biophysics,
extracellular vesicles   lung cancer   liquid biopsy   biosensors   early detection   precision medicine   nanotechnology  

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

A Two-Phase Epigenome-Wide Four-Way Gene–Smoking Interaction Study of Overall Survival for Early-Stage Non-Small Cell Lung Cancer

Medicine, Respiratory System, Oncology,
epigenomics   four-way interaction   gene–smoking interaction   non-small cell lung cancer   survival analysis   DNA methylation   molecular mechanisms  

Study on the Four-Way Gene-Smoking Interaction and Survival in Early-Stage Non-Small Cell Lung Cancer Research Background Lung cancer is one of the most prevalent malignancies worldwide and a leading cause of cancer-related mortality. According to global cancer statistics, approximately 2.5 million new cases are diagnosed annually, with 1.8 million...