Sustained Amphiregulin Expression in Intermediate Alveolar Stem Cells Drives Progressive Fibrosis

Medicine, Respiratory System, Life Sciences, Biochemistry, Immunology,
alveolar stem cells   Amphiregulin   fibrosis   IPF   disease severity   neutralizing antibody  

Persistent Expression of Amphiregulin (AREG) in Intermediate Alveolar Stem Cells Drives Progressive Pulmonary Fibrosis Background Fibrotic diseases are a leading cause of up to 45% of deaths in developed countries. Pulmonary fibrosis is a disease characterized by alveolar structure damage and impaired gas exchange, with Idiopathic Pulmonary Fibrosi...

Context-Dependent Roles of Mitochondrial LonP1 in Orchestrating the Balance Between Airway Progenitor Versus Progeny Cells

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Immunology,
mitochondrial deficiency   airway progenitor cells   Bok expression   COPD   LonP1   stress response   cell imbalance  

Background and Problem In recent years, there has been significant progress in research on the multifaceted roles of mitochondria within cells. Aside from being the energy source of the cell, mitochondria also play crucial regulatory roles in processes such as cell proliferation, differentiation, and self-renewal, attracting widespread attention in...

Stress-Induced Eosinophil Activation Contributes to Postoperative Morbidity and Mortality After Lung Resection

Medicine, Infectious Diseases, Respiratory System, Basic Medical Sciences, Life Sciences, Immunology,
stress   eosinophils   lung resection   postoperative complications   lung injury  

Research Background With global population aging, the number of lung resection surgeries has increased significantly, including primary lung cancer resection, removal of lung metastases, and surgeries to treat lung infections or emphysema. However, little is known about the systemic stress response after thoracic surgery and interventions to improv...

Mechanical Ventilation Guided by Driving Pressure Optimizes Local Pulmonary Biomechanics in an Ovine Model

Engineering, Mechanical Engineering, Medicine, Respiratory System, Anesthesiology, Medical Imaging, Life Sciences, Bioengineering,
Mechanical ventilation   Driving pressure   Pulmonary biomechanics   Acute respiratory distress syndrome   Whole-lung image segmentation  

Optimization of Respiratory Pressure Under Mechanical Ventilation Guidance - A Study on Improving Local Lung Biomechanics Mechanical ventilation is commonly used in clinical practice to treat acute respiratory distress syndrome (ARDS) and prevent pulmonary complications after general anesthesia. However, mechanical ventilation can cause harmful str...

Super-relaxed Myosins Contribute to Respiratory Muscle Hibernation in Mechanically Ventilated Patients

Medicine, Respiratory System, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Biophysics,
super-relaxed myosins   mechanical ventilation   respiratory muscle hibernation   ICU   diaphragm weakness  

The Impact of Super-Relaxed Myosin on Diaphragm Dysfunction in Ventilated Patients Background Weak diaphragm contraction is a common problem in patients receiving mechanical ventilation in intensive care units (ICUs). This leads to difficulties in weaning patients off ventilators, increases mortality rates, and imposes a significant economic burden...

A Self-Amplifying RNA Vaccine Prevents Enterovirus D68 Infection and Disease in Preclinical Models

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Bioengineering, Immunology, Microbiology,
RNA vaccine   Enterovirus D68   nonenveloped virus   antibody responses   vaccine platform   antigenic diversity   preventive vaccine  

A Study on Self-Amplifying RNA Vaccine for Prevention of Enterovirus D68 Infection and Disease in Clinical Models 1. Background In recent years, rapid response to emerging infectious diseases and vaccine development have received much attention. Particularly, the emergence of the novel coronavirus (SARS-CoV-2) has led to rapid advancement in RNA va...