Molecular and Circuit Determinants in the Globus Pallidus Mediating Control of Cocaine-Induced Behavioral Plasticity

Scientific News Report: The Molecular and Neural Circuit Mechanisms in the Globus Pallidus for Controlling Cocaine-Induced Behavioral Plasticity In the field of the neurobiology of drug abuse, this paper provides a new perspective for exploring cocaine-induced behavioral plasticity and neural circuit regulation. The research team centered on the Gl...

Negative Feedback Control of Hypothalamic Feeding Circuits by the Taste of Food

I. Research Background The taste of food has a significant impact on the feeding motivation of animals. Previous research has shown that taste, as a positive feedback signal, can enhance the feeding motivation of animals. However, in recent years, studies on whether taste also plays a role in suppressing feeding and helping achieve negative feedbac...

Transformation of Neural Coding for Vibrotactile Stimuli Along the Ascending Somatosensory Pathway

Research Background The neural transduction mechanisms of tactile vibration coding have been a hot topic in neuroscience research. In daily life, we acquire information about the external environment through the perception of vibrations, such as phone vibration alerts or car proximity warnings. In mammals, high-frequency vibration perception is mai...

Ketamine Alleviates NMDA Receptor Hypofunction Through Synaptic Trapping

Ketamine Alleviates NMDA Receptor Hypofunction Through Synaptic Trapping

With the advancement of neuroscience research, the crucial role of N-methyl-D-aspartate receptors (NMDA receptors, NMDAR) in neurotransmission and cognitive functions has become increasingly clear. NMDARs are a type of ionotropic glutamate receptor that play an important role in neuronal synapses, responsible for rapid excitatory transmission and s...

Antisense Oligonucleotides Enhance SLC20A2 Expression and Suppress Brain Calcification in a Humanized Mouse Model

Antisense Oligonucleotides Enhance SLC20A2 Expression and Suppress Brain Calcification in a Humanized Mouse Model

Antisense Oligonucleotide Enhances SLC20A2 Expression and Inhibits Brain Calcification in Humanized Mouse Models Background and Research Questions Primary Familial Brain Calcification (PFBC) is an age-related neurogenetic disorder, characterized by bilateral calcifications in brain regions such as the basal ganglia, thalamus, and cerebellum. PFBC p...