Intravenous Administration of an AAV9 Vector Ubiquitously Expressing C1ORF194 Gene Improved CMT-like Neuropathy in C1ORF194-/- Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
CMT disease   C1ORF194   gene therapy   AAV9   neuropathy   motor ability   sensory nerves  

Research Report on the Improvement of CMT-like Neuropathy via AAV9 Vector-based C1ORF194 Gene Therapy Background and Research Motivation Charcot-Marie-Tooth disease (CMT) is a rare group of genetically heterogeneous neuromuscular disorders characterized by progressive muscle weakness and atrophy, along with sensory loss. Despite extensive preclinic...

GYS1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
GYS1   antisense oligonucleotide   epilepsy   Lafora disease   glycogen synthesis   neuroinflammation   neurodegeneration  

GYS1 Antisense Therapy Inhibits Pathogenic Aggregates and Epileptiform Discharges in a Mouse Model of Lafora Disease Background and Objectives Lafora disease (LD) is a devastating autosomal recessive genetic disorder characterized by epilepsy and rapidly progressive dementia in adolescence. The disease primarily involves mutations in the EPM2A or E...

D1R-5-HT2AR Uncoupling Reduces Depressive Behaviors via HDAC Signaling

Medicine, Basic Medical Sciences, Psychiatry, Neurology, Clinical Psychology, Life Sciences, Cell Biology, Biochemistry, Immunology,
D1R   5-HT2AR   depression   HDAC   signaling   neurotransmitter   therapeutic strategies  

D1R-5-HT2AR Uncoupling Alleviates Depressive Behaviors Through HDAC Signaling Research Background Major depressive disorder (MDD) is a globally prevalent and life-threatening mental illness, closely associated with poor physical health. Despite the availability of various treatments, including medications and psychotherapy, many patients exhibit po...

Complex Mosaicism and Aneuploid Cells in Human Embryo Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Genetics,
human embryo   mosaicism   aneuploidy   single-cell sequencing   embryo development  

Study of Complex Mosaicism in Human Embryos: Revealing Extensive Aneuploidy During Early Embryonic Development Background and Research Objectives Pre-implantation Genetic Testing for Aneuploidy (PGT-A) is a widely used technology in in vitro fertilization (IVF) aimed at screening out abnormal embryos to improve implantation and live birth rates. Ho...

Enhanced MRI-based Brain Tumour Classification with a Novel Pix2Pix Generative Adversarial Network Augmentation Framework

Information Science, Artificial Intelligence, Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Oncology,
brain tumours   conditional deep convolutional neural network   generative adversarial networks   Pix2Pix model   synthetic data  

Here’s the translation of the report, ensuring all content is preserved as requested: The research presents an enhanced MRI-based brain tumor classification method using a novel Pix2Pix Generative Adversarial Network (GAN) augmentation framework, effectively addressing challenges in data scarcity and privacy while improving diagnostic accuracy. Doe...