Age-dependent Loss of Hapln1 Erodes Vascular Integrity via Indirect Upregulation of Endothelial ICAM1 in Melanoma

Medicine, Medical Laboratory Science, Geriatrics, Oncology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology,
Hapln1   Melanoma   Vascular Integrity   ICAM1   Aging   Extracellular Matrix  

Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma In a research article titled “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma” published in Nature Aging in March 2024, significant findings have been revealed. The study...

Principal Component-Based Clinical Aging Clocks Identify Signatures of Healthy Aging and Targets for Clinical Intervention

Medicine, Environmental and Public Health, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology,
Principal Component Analysis   Clinical Aging Clocks   Healthy Aging   Metabolic Dysregulation   Caloric Restriction  

Clinical Aging Clock Based on Principal Components Reveals Characteristics of Healthy Aging and Targets for Clinical Interventions Background of the Study As the population ages, promoting healthy aging and slowing down biological aging has become an important issue. To accurately predict all-cause mortality and obtain feasible measures to promote ...

GDF1 Ameliorates Cognitive Impairment Induced by Hearing Loss

Medicine, Geriatrics, Neurology, Life Sciences, Biochemistry,
GDF1   Cognitive Function   Hearing Loss   Alzheimer's Disease   Synaptic Function   Neurodegeneration  

Improvement of Cognitive Impairment Induced by Hearing Loss Background Alzheimer’s Disease (AD) is a common dementia characterized by extracellular amyloid plaques formed by aggregation of amyloid-β (Aβ) and intracellular neurofibrillary tangles formed by aggregated tau protein. Epidemiological studies indicate a close correlation between hearing l...

A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation, and shortened lifespan

Medicine, Geriatrics, Life Sciences, Immunology,
nutrient signaling   mTORC1   parenchymal damage   myeloid inflammation   lifespan  

Research on the Impact of Nutritional Signals on the Lifespan of Mice Background and Motivation In recent years, the intensification of global aging has posed unprecedented challenges to medicine, socio-economics, and philosophy. By 2050, the global population aged 65 and above is expected to grow from 5% at the beginning of the 20th century to 17%...

DDX5 Inhibits Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis via Alternative Splicing and G-Quadruplex Unwinding

Medicine, Orthopedics, Basic Medical Sciences, Geriatrics,
osteoarthritis   hyaline cartilage   fibrosis   DDX5   alternative splicing   G-quadruplex  

The Novel Mechanism of DDX5 in Inhibiting Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis Background Osteoarthritis (OA) is a chronic degenerative disease characterized mainly by the degradation, degeneration, and osteophyte formation of joint cartilage. Hyaline cartilage fibrosis is often considered the end-stage lesion of OA, leading...