Inhibition of S6K Reduces Age-Related Inflammation and Extends Lifespan through the Endosomal-Lysosomal System Research Background and Problem Description As organisms age, chronic low-grade inflammation (inflammaging) and declined immune function (immunosenescence) become important pathological foundations of many diseases in the elderly, such as ...

Research on the Essence of Epigenetic Aging from a Single-Cell Perspective Research Background As biological research progresses, scientists have discovered that changes in DNA methylation (DNAm) constitute one of the most reliable predictors of age—known as the epigenetic clock. However, the mechanisms underlying what these clocks precisely measur...

Scientific Research Report: Plasma Membrane Damage Limits Yeast Replicative Lifespan and Induces Premature Senescence in Human Fibroblasts Background and Research Motivation Plasma Membrane Damage (PMD) is a phenomenon experienced by all cell types in response to environmental disturbances and spontaneous cellular activities. Previous studies have ...

Epidemiological Study on Menopausal Hormone Therapy and Breast Cancer Risk Introduction This study aims to explore the relationship between Menopausal Hormone Therapy (HT) and the risk of Breast Cancer (BC). While HT can relieve menopausal symptoms in women (such as hot flashes, fatigue, and urinary pain), it may also pose other health risks like a...

The Role of IL-33 in Promoting Tumor Growth in Pancreatic Cancer Tissue and its Potential as a Therapeutic Target Background Introduction Pancreatic Cancer (PDA) is one of the most lethal malignancies worldwide, characterized by rapid clinical progression and poor treatment responses, with a five-year survival rate of only 13%. In the United States...