Glycometabolic Reprogramming-Induced XRCC1 Lactylation Confers Therapeutic Resistance in ALDH1A3-Overexpressing Glioblastoma

Medicine, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry,
Glioblastoma   Metabolic reprogramming   Lactylation   Therapeutic resistance   ALDH1A3   DNA repair  

Background Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults, characterized by high recurrence and mortality rates. Despite active chemotherapy and radiotherapy post-surgery, GBM remains insensitive to existing treatment regimens, and patients usually have a poor prognosis. Recent studies indicate that the...

Timing of Anticoagulation Resumption and Risk of Ischemic and Hemorrhagic Complications in Patients with Intracranial Hemorrhage and Mechanical Heart Valves

Medicine, Neurology, Neurosurgery, Hematology, Cardiovascular System,
Anticoagulation   Ischemic Complications   Hemorrhagic Complications   Mechanical Heart Valves   Intracranial Hemorrhage  

Exploration of Anticoagulation Therapy Resumption Time After ICH in Mechanical Heart Valve Patients Background and Motivation For patients with mechanical heart valves, determining the appropriate time to resume oral anticoagulation therapy after experiencing an intracerebral hemorrhage (ICH) remains a significant clinical challenge. These patients...

Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County, MN, 2011–2022

Medicine, Neurology, Neurosurgery, Medical Imaging, Life Sciences,
Primary Progressive Aphasia   Primary Progressive Apraxia of Speech   Epidemiology   Prospective Study   Radiographic Characteristics  

Study on the Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County (2011-2022) Background and Study Objectives Primary Progressive Aphasia (PPA) and Primary Progressive Apraxia of Speech (PPAOS) are rare neurodegenerative diseases that respectively lead to the degeneration of language abilities and spe...

p39 Affects Myelin Formation in Cerebral Ischemic Injury

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry,
ischemic   p39   myelin   p35   central nervous system   neuroprotection  

The Role of p39 in Cerebral Ischemic Injury Background Introduction Stroke is an extremely serious public health problem, with current research mainly focusing on injury mechanisms and new target identification. p39, as an activator of CDK5 (Cyclin-dependent kinase 5), plays a crucial role in various diseases. This article mainly investigates the r...

Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-Ion Rat

Medicine, Basic Medical Sciences, Anesthesiology, Neurology, Neurosurgery,
optogenetics   neuron inhibition   posterior insular cortex   trigeminal neuropathic pain   CCI-Ion  

Optogenetic Inhibition of Insular Cortex Glutamatergic Neurons Regulates Trigeminal Neuropathic Pain Introduction and Background Trigeminal neuropathic pain (TNP) is a severe facial disorder characterized by rapid and intense stabbing pain attacks that spread along the cutaneous segments of the trigeminal nerve. TNP occurs almost twice as frequentl...