Long-Term Outcomes of High-Risk Medulloblastoma Treatment Background Medulloblastoma is one of the most common malignant brain tumors in children. Despite advancements in treatment, the prognosis for high-risk medulloblastoma patients remains poor. High-risk medulloblastoma typically includes patients with metastatic disease, TP53 mutations, MYC/MY...

Clinical and Biological Heterogeneity in MYC/MYCN-Amplified Medulloblastoma Academic Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Despite recent advances in treatment, approximately 30% of patients still die from the disease, and survivors often face long-term treatment-related complications. Amplifi...

Study on Relapse Patterns of Intracranial Ependymoma Background Ependymoma (EPn) is a rare but highly heterogeneous central nervous system tumor, particularly common in children. Despite significant advances in the biology and molecular characteristics of ependymoma in recent years, its relapse patterns remain unclear. The timing and location of re...

Diagnostic Accuracy and Value of 68Ga-Pentixafor PET/MRI in Tumor Localization for Cushing’s Disease Academic Background Cushing’s disease is the primary cause of Cushing’s syndrome, characterized by excessive secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland, often due to pituitary adenomas. Patients with chronic hypercortis...

Fabrication and In Vivo Testing of a Sub-mm Duckbill Valve for Hydrocephalus Treatment Academic Background Hydrocephalus is a complex pathological condition characterized by the accumulation of cerebrospinal fluid (CSF) in the cranium due to an imbalance between CSF production and absorption. This accumulation leads to increased intracranial pressu...