ENPP1 Induces Blood–Brain Barrier Dysfunction and Promotes Brain Metastasis Formation in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Medicine, Neurology, Neurosurgery, Oncology,
blood-brain barrier   brain metastasis   HER2-positive breast cancer   ENPP1   insulin signaling pathway   endothelial cell dysfunction   prognostic biomarker  

The Role of ENPP1 in Brain Metastasis of HER2-Positive Breast Cancer Academic Background Brain metastasis (BM) is a severe neurological complication in patients with HER2-positive breast cancer (HER2+ BC), with an incidence rate as high as 50%. The formation of brain metastasis is closely related to how tumor cells cross the blood-brain barrier (BB...

Meningeal Solitary Fibrous Tumor Cell States Phenocopy Cerebral Vascular Development and Homeostasis

Medicine, Neurology, Neurosurgery, Oncology,
meningeal solitary fibrous tumor   single-cell RNA sequencing   spatial transcriptomics   cell-cell interactions   cerebral vascular development   tumor microenvironment   WHO histological grading  

Single-Cell and Spatial Transcriptomics Study of Meningeal Solitary Fibrous Tumors Academic Background Meningeal Solitary Fibrous Tumors (SFTs) are rare mesenchymal tumors originating from the meninges of the central nervous system (CNS). Although SFTs are histologically similar to other meningeal tumors (such as meningiomas), their unique clinical...

Analysis of HER2 Expression Changes from Breast Primary to Brain Metastases and the Impact of HER2-Low Expression on Overall Survival

Medicine, Neurosurgery, Oncology,
breast cancer   brain metastases   HER2 expression   survival analysis   noninvasive diagnostics  

HER2 Expression Dynamics in Breast Cancer Brain Metastases and Its Impact on Survival Background Breast cancer is one of the most common cancers among women worldwide, and brain metastases (BrMs) pose a significant challenge for patients. In recent years, with the prolonged survival of breast cancer patients, the incidence of brain metastases has g...

Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4400 Tumors

Medicine, Neurology, Neurosurgery, Oncology,
glioma   molecular classification   survival rate   risk stratification   genomic diversity   prognostic features   molecular markers  

Molecular Classification and Prognostic Features of Gliomas Background Introduction Glioma is the most common malignant brain tumor in adults, and its classification, risk stratification, and treatment standards have undergone significant changes in recent years. With the introduction of molecular markers, the classification system for gliomas has ...

MYC-Dependent Upregulation of the De Novo Serine and Glycine Synthesis Pathway is a Targetable Metabolic Vulnerability in Group 3 Medulloblastoma

Medicine, Neurology, Neurosurgery, Oncology,
medulloblastoma   MYC amplification   metabolic vulnerability   serine synthesis   glycine synthesis   PHGDH inhibition   therapeutic strategy  

Targeting the Serine/Glycine Synthesis Pathway in MYC-Driven Medulloblastoma Background Medulloblastoma is one of the most common malignant brain tumors in children, accounting for a significant proportion of childhood cancer deaths. Based on molecular characteristics, medulloblastoma is classified into four major subgroups: WNT, SHH, Group 3 (MBGr...