Generative Reconstruction of Multimodal Cardiac Waveforms from a Single Vibrational Cardiography Sensor

Engineering, Electrical Engineering, Information Science, Artificial Intelligence, Medicine, Medical Imaging, Cardiovascular System, Life Sciences, Bioengineering,
cardiac monitoring   generative adversarial network   multimodal waveform   wearable sensor   vibrational cardiography   electrocardiography   non-invasive blood pressure  

Multimodal Cardiovascular Waveform Generation from a Single Vibrational Cardiography Sensor Background Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality worldwide, affecting hundreds of millions of patients each year and imposing a tremendous burden on global healthcare systems. According to literature, billions o...

Randomized Explainable Machine Learning Models for Efficient Medical Diagnosis

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Urology, Nephrology, Medical Imaging, Oncology, Cardiovascular System,
medical diagnosis   randomized models   explainable artificial intelligence   extreme learning machines   random vector functional link   big data   deep learning  

New Breakthrough in Intelligent Medical Diagnosis: Randomized Explainable Machine Learning Models Drive Efficient Medical Diagnostics I. Academic Background and Research Motivation In recent years, Deep Learning (DL) models have played a crucial role in the field of healthcare. By processing vast amounts of medical data, DL significantly improves t...

Aging Promotes Reactivation of the Barr Body at Distal Chromosome Regions

Medicine, Rheumatology and Immunology, Obstetrics and Gynecology, Geriatrics, Neurology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
aging   Barr body   X chromosome inactivation   escape genes   chromatin accessibility   sex differences   epigenetics  

1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...

Gut Microbiota-Dependent Increase in Phenylacetic Acid Induces Endothelial Cell Senescence During Aging

Medicine, Geriatrics, Gastroenterology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Microbiology,
gut microbiota   phenylacetic acid   endothelial cell senescence   aging mechanisms   cardiovascular disease   oxidative stress  

Molecular Mechanisms of Gut Microbiota and Its Metabolites Mediating Endothelial Cell Senescence During Aging – Interpretation of Latest Results from Nature Aging I. Research Background and Significance Against the backdrop of a deeply aging human society, cardiovascular disease (CVD) has become one of the greatest health threats to the global elde...

Role of Recurrent Somatic Mutation and Progerin Expression in Early Vascular Aging of Chronic Kidney Disease

Medicine, Basic Medical Sciences, Geriatrics, Nephrology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Genetics,
chronic kidney disease   vascular aging   somatic mutations   progerin   vascular smooth muscle cells   clonal expansion   molecular mechanisms  

1. Academic Background and Research Rationale Chronic Kidney Disease (CKD) is a global public health challenge. Epidemiological data indicate that CKD affects approximately 10–12% of the world’s population, acting as a major driver of cardiovascular disease (CVD) mortality worldwide. CKD patients often display “Early Vascular Aging” (EVA) phenomena...

Adult Human Heart Extracellular Matrix Improves Human iPSC-CM Function via Mitochondrial and Metabolic Maturation

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
extracellular matrix   iPSC-derived cardiomyocyte   functional maturation   mitochondrial maturation   metabolic maturation   cell therapy  

1. Academic Background Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide. After a myocardial infarction, up to one billion cardiomyocytes (CM) can be lost in just a few hours. However, adult myocardial tissue itself has extremely low regenerative capacity, which means the ...