Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
muscle-derived miR-126   TDP-43 axonal synthesis   neuromuscular junction   ALS models   neurodegeneration   local protein synthesis  

Muscle-derived miR-126 Regulates Axonal Local Synthesis of TDP-43 to Maintain Neuromuscular Junction Integrity in ALS Models — Review of a Nature Neuroscience Article I. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset motor neuron disease, primarily characterized by neuromuscular junction (NMJ)...

C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
C9orf72   hexanucleotide repeat expansion   microglia   amyotrophic lateral sclerosis   single-nuclei transcriptome   endolysosomal pathway   genetic mechanism  

C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS Patients — In-depth Report on the November 2025 Issue of Nature Neuroscience 1. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a disabling neurodegenerative disease characterized by progressive loss of motor neurons, with most patients dyi...

Brain Tumors Induce Widespread Disruption of Calvarial Bone and Alteration of Skull Marrow Immune Landscape

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Hematology, Medical Imaging, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
brain tumor   calvarial bone   skull marrow   immune microenvironment   single-cell RNA sequencing   osteoclast   immune cell alteration  

A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...

Recurrent Pattern Completion Drives the Neocortical Representation of Sensory Inference

Information Science, Artificial Intelligence, Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
neocortex   pattern completion   sensory inference   illusory contours   visual cortex   neural coding  

Academic Background: Exploring Perceptual Inference and Neural Mechanisms In everyday life, our sensory systems often encounter incomplete or ambiguous information. For instance, when objects are occluded, the brain relies on prior experience and expectations to infer the whole. This inferential ability is not only a core function of the human visu...

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
aberrant splicing   C9orf72   repeat expansion   ALS   frontotemporal dementia   DPR proteins   therapeutic targets  

New Pathway for ALS/FTD-Related C9orf72 Pathogenesis Revealed by Latest Nature Neuroscience Study Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are among the most challenging neurodegenerative diseases in clinical medicine, with complex pathogenesis that remains insufficiently expl...

In Silico Modeling and Validation of the Effect of Calcium-Activated Potassium Current on Ventricular Repolarization in Failing Myocytes

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Biochemistry, Bioengineering, Biophysics,
calcium-activated potassium channels   heart failure   ventricular repolarization   electrophysiological modeling   pharmacological modulation   arrhythmia   atrial fibrillation  

The Effect of Calcium-Activated Potassium Channels (SK Channels) on Repolarization in Failing Ventricular Myocytes—A Computational Modeling Study Research Background and Academic Significance Heart failure (HF) is a severe and prevalent cardiac disease, characterized by a comprehensive deterioration of the heart’s electrophysiological and contracti...

Aging Promotes Reactivation of the Barr Body at Distal Chromosome Regions

Medicine, Rheumatology and Immunology, Obstetrics and Gynecology, Geriatrics, Neurology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
aging   Barr body   X chromosome inactivation   escape genes   chromatin accessibility   sex differences   epigenetics  

1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...

Epigenetic Editing at Individual Age-Associated CpGs Affects the Genome-wide Epigenetic Aging Landscape

Medicine, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
epigenetic editing   DNA methylation   CpG sites   aging biomarkers   genome-wide   CRISPR   bystander effects  

Unveiling the Mystery of the Epigenetic Aging Clock: A Review of Research on the Impact of Epigenetic Editing at Single Age-Associated CpG Sites on the Genome-wide Epigenetic Aging Landscape I. Research Background and Scientific Questions Epigenetics, especially DNA methylation, has become a cutting-edge frontier in aging mechanism research in rece...