Unsaturation of Fatty Acids Promotes Pore-Forming Activity of Bax and Bak in Apoptosis Background Apoptosis is the major form of programmed cell death, involved in fundamental biological processes such as embryonic development, tissue homeostasis, and immune system functions. Dysregulation of apoptosis can lead to neurodegenerative diseases and tum...

Orthogonal Proteogenomic Analysis Identifies Druggable PA2G4-MYC Axis in 3q26 AML Acute myeloid leukemia (AML) is a highly heterogeneous and aggressive malignancy. In particular, the 3q26 chromosomal abnormality subtype of AML has a complex pathogenic mechanism and lacks effective targeted therapies. To address this challenge, Matteo Marchesini and...

This paper aims to explore the physiological importance of glycolysis in neuronal metabolic processes. For a long time, although neuronal activity mainly relies on glucose for energy, neurons have relatively weak glucose metabolism, mainly through glycolysis rather than other metabolic pathways. This phenomenon can be attributed to the sustained de...

Differential Effects of Exercise Timing on Skeletal Growth in Mice Introduction Skeletal growth is crucial for adult height and bone health. Studies have shown that exercise can effectively increase bone density, but the optimal exercise timing remains unclear. This study aimed to investigate the optimal exercise timing by comparing the effects of ...

Layer-Dependent Effects of Chronic Neural Electrode Implants on Neural Functional Connectivity in Mice Introduction This study explores the long-term effects of chronically implanted microelectrodes on neural functional connectivity within the brains of C57BL6 wild-type mice. Implanted intracerebral electrodes enable the recording and electrical st...