Comprehensive Academic Report on Scientific Paper Research Background Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system (CNS), affecting approximately 2.8 million people worldwide. The pathological mechanisms of this disease are mainly related to autoimmune-mediated demyelination and axonal transectio...

Characteristics, Quantity, and Spatial Distribution of Human Cervical Vagus Nerve and its Cardiac Superior Branch Nerve Fibers Introduction In modern medicine, Vagus Nerve Stimulation (VNS) is widely used to treat various diseases such as epilepsy, obesity, depression, and heart diseases. Although the overall Vagus nerve stimulation method has prov...

Whole-Brain Mapping of Specific Orbitofrontal Cortex Neuron Inputs and Outputs in Mice Research on the mouse brain has always been an important topic in neuroscience, especially studies on the orbitofrontal cortex (ORB). The ORB plays a key role in reward processing, decision making, behavioral flexibility, and emotional regulation. In recent years...

Background Introduction The brain is composed of different subtypes of neurons, which form complex neural networks through local and long-range synaptic connections. Understanding the functions of these neural networks requires knowledge of their connection patterns (projectome) and neuronal dynamics. Although advancements in mesoscale connectomics...

Single-Cell Analysis of Anti-BCMA CAR-T Cell Therapy in Patients with Central Nervous System Autoimmune Diseases Introduction Chimeric Antigen Receptor (CAR) T-cell therapy has shown potential long-term control in treating central nervous system (CNS) autoimmune diseases. This paper investigates the effects of anti-BCMA (B-cell maturation antigen) ...