Combination of Biological Aging and Genetic Susceptibility Helps Identifying At-Risk Population of Venous Thromboembolism: A Prospective Cohort Study of 394,041 Participants

Combining Biological Aging and Genetic Susceptibility to Identify High-Risk Populations for Venous Thromboembolism Academic Background Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most fatal cardiovascular disease globally. The incidence of VTE is closely related to age, particularly i...

The Role of Cognitive Load on Interlimb Differences in Motor Coordination in Older Adults

The Impact of Cognitive Load on Interlimb Differences in Motor Control in Older Adults Academic Background In daily life, we often observe that the dominant hand (e.g., the right hand in right-handed individuals) performs better than the non-dominant hand in simple tasks. However, these interlimb differences may be influenced by task complexity and...

Choroid Plexus Aging: Structural and Vascular Insights from the HCP-Aging Dataset

Research on Choroid Plexus Aging and Cerebrospinal Fluid Dynamics Background Introduction The choroid plexus (CHP) is a highly vascularized structure located within the brain ventricles, primarily responsible for the production of cerebrospinal fluid (CSF) and the clearance of metabolic waste. It plays a crucial role in maintaining neurofluid homeo...

Association between Choroid Plexus Volume and Cognitive Function in Community-Dwelling Older Adults without Dementia: A Population-Based Cross-Sectional Analysis

Association Between Choroid Plexus Volume and Cognitive Function in Community-Dwelling Older Adults: A Research Study Academic Background With the increasing global aging population, the number of dementia patients is rising annually. Early identification of older adults with declining cognitive function and guiding them toward preventive and thera...

Mechanisms of Age-Associated Variation in Immune Cell Regeneration Across Individuals

The functional decline of the immune system with aging is characterized by an increase in innate immune cells (e.g., granulocytes) and a decrease in adaptive immune cells (e.g., B cells). This imbalance in the immune system is closely related to the onset of various diseases, particularly myeloid leukemia and immune deficiencies common in the elder...