1. Research Background and Academic Significance Alzheimer’s Disease (AD) is the most common form of dementia worldwide, accounting for about 60–80% of all dementia cases. The primary affected population is individuals over 65 years old, with characteristic pathological features including the deposition of amyloid-β plaques, neurofibrillary tangles...

Mitochondria-Enriched Hematopoietic Stem Cells Reveal Enhanced Self-Renewal Activity in Aged Bone Marrow: In-Depth Analysis of the Latest Study in Nature Aging I. Academic Background and Research Significance Hematopoietic stem cells (HSCs) are the essential foundation underlying life-long production of blood and immune cells. However, with aging, ...

Mechanistic Study on How Retrotransposon-derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity — A New Research Review from Nature Aging I. Research Background and Scientific Significance Nearly half of the DNA in the human and mammalian genome is made up of retrotransposons, sequences that originally existed as “parasitic molecules” ...

I. Research Background and Scientific Question Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with pathological features mainly including neuronal loss, neurofibrillary tangles, and senile plaques (mainly formed by amyloid-β [Aβ] deposition). According to statistics, the number of AD patients continues to rise each...

mRNA Metabolism Regulator Human Antigen R (HuR) Regulates Age-Related Hearing Loss in Aged Mice — A Systematic Study of Molecular Pathological Mechanisms and Therapeutic Intervention 1. Academic Background and Scientific Questions Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common sensory disorders in the global e...