Intermittent Hypoxia Exacerbates Anxiety in High-fat Diet-Induced Diabetic Mice by Inhibiting TREM2-Regulated IFNAR1 Signaling

Medicine, Respiratory System, Psychiatry, Endocrinology, Neurology,
Type 2 Diabetes Mellitus   Obstructive Sleep Apnea   Anxiety   Microglia   TREM2   IFNAR1   Cognition  

Over the past few decades, the incidence of type 2 diabetes mellitus (T2DM) has been on the rise, becoming a global public health issue. T2DM not only affects patients’ metabolic levels but also has profound impacts on cognitive function and mental health. Studies have shown that patients with T2DM exhibit brain structural abnormalities, a decline ...

Microglial PDCD4 Deficiency Mitigates Neuroinflammation-Associated Depression via Facilitating Daxx Mediated PPARγ/IL-10 Signaling

Medicine, Infectious Diseases, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   PDCD4   Neuroinflammation   Depression   PPARγ   IL-10  

Deletion of Microglia PDCD4 Alleviates Neuroinflammation-Associated Depression by Promoting DAXX-Mediated PPARγ/IL-10 Signaling Background In recent years, neuroinflammatory processes have been demonstrated to be associated with various psychiatric disorders, including schizophrenia, depression, and anxiety. A common feature of these diseases is th...

Single-Cell RNA Sequencing Reveals the Evolution of the Immune Landscape During Perihematomal Edema Progression After Intracerebral Hemorrhage

Medicine, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
intracerebral hemorrhage   single cell RNA sequencing   perihematomal edema   immune cell   osteopontin  

Single-cell RNA Sequencing Reveals Evolution of Immune Landscape in Perihematomal Edema Post Hemorrhagic Stroke Research Background Intracerebral hemorrhage (ICH) is one of the global health threats, renowned for its high disability and mortality rates. Among the secondary brain injuries caused by ICH, the formation of perihematomal edema (PHE) is ...

Regulation of Neuroinflammation and Demyelination by Cystatin F Following Murine Coronavirus Infection of the Central Nervous System

Medicine, Infectious Diseases, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Biochemistry, Immunology,
Cystatin F   neuroinflammation   demyelination   murine coronavirus   central nervous system   immune response  

The Role of Cystatin F in Regulating Neuroinflammation and Demyelination in Spinal Cord Poliovirus Infection Background Knowledge Cystatin F is a secreted lysosomal cysteine protease inhibitor associated with every stage of virus-related neurological diseases, including host defense, demyelination, and myelination. However, research on how Cystatin...

Inhibition of Mannan-Binding Lectin Associated Serine Protease-2 Reduces Cognitive Deficits in a Mouse Model of Severe Traumatic Brain Injury

Medicine, Neurology, Neurosurgery, Life Sciences, Immunology,
Traumatic Brain Injury   Lectin Pathway   MASP-2   Cognitive Deficits   Antibody Therapy   Mouse Model  

Review of Research on the Treatment Potential for Cognitive Deficits in Traumatic Brain Injury Research Background Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. In Europe, the annual incidence of TBI is at least 4 million cases, imposing a heavy burden on patients, society, and health systems, yet the available ...

Differential Training Benefits and Motor Unit Remodeling in Wrist Force Precision Tasks Following High and Low Load Blood Flow Restriction Exercises Under Volume-Matched Conditions

Differential Training Benefits and Motor Unit Remodeling in Wrist Force Precision Tasks Following High and Low Load Blood Flow Restriction Exercises Under Volume-Matched Conditions

Medicine, Orthopedics, Neurology, Sports Medicine, Life Sciences, Bioengineering,
hypoxia   training load   force regulation   motor unit   electromyography  

Study on the Differential Effects of Blood Flow Restriction Training on Strength Gains and Precise Force Control Research Background Blood Flow Restriction (BFR) training, an emerging method for enhancing muscle strength, has garnered attention from researchers and clinical medicine in recent years. BFR training with low-load resistance exercise en...