ABHD6 Drives Endocytosis of AMPA Receptors to Regulate Synaptic Plasticity and Learning Flexibility

ABHD6 Drives Endocytosis of AMPA Receptors to Regulate Synaptic Plasticity and Learning Flexibility Research Background In the exploration of the neural system’s mechanisms, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) maintain the tuning ability of neurons in both resting and active states through the regulation of...

Accumulation of NMDA Receptors in Accumbal Neuronal Ensembles Mediates Increased Conditioned Place Preference for Cocaine After Prolonged Withdrawal

Study Reveals Molecular Mechanisms of Enhanced Cocaine Craving in Rats During Withdrawal Background Introduction The issue of relapse in drug abuse poses a significant challenge in addiction treatment. According to related research, relapse behaviors in drug addiction are often triggered by environmental cues associated with drug use. This phenomen...

Contralateral Delay Activity and Alpha Lateralization Reflect Retinotopic and Screen-Centered Reference Frames in Visual Memory

Contralateral Delay Activity and Alpha Lateralization Reflect Retinotopic and Screen-Centered Reference Frames in Visual Memory

Academic Report on “Contralateral Delay Activity and Alpha Lateralization Reflect Retinotopic and Screen-Centered Reference Frames in Visual Memory” Introduction The visual system is organized in a lateralized manner, with the left and right visual fields processed by the contralateral cerebral cortex. This organization applies not only to percepti...

Signal Peptide Peptidase-Like 2B Modulates the Amyloidogenic Pathway and Exhibits an Aβ-Dependent Expression in Alzheimer’s Disease

New Findings in Alzheimer’s Disease Research: The Regulatory Role of Signal Peptide Peptidase-Like 2b in the β-Amyloid Cascade Alzheimer’s Disease (AD) is a complex neurodegenerative disorder characterized by the abnormal accumulation of β-amyloid peptides (Aβ) in brain tissue and the formation of intracellular neurofibrillary tangles. The abnormal...

Dissecting Gene Expression Networks in the Developing Hippocampus through the Lens of NEIL3 Depletion

Dissecting Gene Expression Networks in the Developing Hippocampus through the Lens of NEIL3 Depletion

Analyzing the Gene Expression Network in Developing Hippocampus from the Perspective of NEIL3 Deficiency Background The hippocampus, a crucial region of the brain, is well-regarded for its key roles in memory consolidation, information processing, and emotional regulation. In the field of neuroscience research, the gene regulatory mechanisms of the...

Central C3a Receptor Modulates LPS-Induced Depressive-like Behaviors

The Regulatory Mechanism of Central Complement C3a Receptor on LPS-Induced Depressive-Like Behavior Introduction With the increasing number of depression patients globally, major depressive disorder (MDD) has become one of the leading causes of disability worldwide. The symptoms, treatment effects, and biological correlations of depression exhibit ...