Major Breakthrough in Brain Science: Multimodal MRI Reveals Brainstem Connectivity Maintaining Human Consciousness and Wakefulness Background Introduction Consciousness comprises two fundamental components: wakefulness and awareness. Despite significant progress in understanding the cortical networks related to consciousness over the past two decad...
Research Background and Motivation Neuropathic pain is a complex and common clinical issue, accompanied by persistent spontaneous pain. Patients often report symptoms such as spontaneous pain, electric shock sensations, and burning pain. The physiological mechanisms behind this type of pain are complex, and reliable research models or biomarkers ar...
New Breakthrough in the Field of Cerebral Vascular Diseases: Clinical Application of Small Optical Coherence Tomography Imaging Probe Academic Background and Research Motivation In recent years, interventional treatment has become the preferred method for cerebrovascular diseases such as cerebral aneurysm, ischemic stroke, arterial dissection, and ...
Encoding of Cerebellar-Olivary Neuronal Ensemble Activity for Tremor Frequency in Mice and Patients with Essential Tremor Research Background Essential Tremor (ET) is a common movement disorder characterized primarily by action tremor, affecting about 20% of the elderly population. The frequency and intensity of tremor are core features of ET. Howe...
This article is written by Jeremy M. Sullivan et al. and published in the journal “Science Translational Medicine” on May 22, 2024, titled “Gain-of-function TRPV4 Mutations in Endothelial Cells Disrupt the Blood-Spinal Cord Barrier and Cause Motor Neuron Degeneration in Mice.” Academic Background The research background of this article revolves aro...
High-Fidelity Fatigue-Resistant Muscle Control Through Closed-Loop Optogenetic Neural Modulation Background Introduction Skeletal muscle is the biological actuator for almost all movements in animals and humans. However, under various neurological conditions, the communication pathways between the central nervous system and neuromuscular components...