Connectome Reorganization Associated with Temporal Lobe Pathology and Its Surgical Resection

Connectome Reorganization Associated with Temporal Lobe Pathology and Its Surgical Resection

Medicine, Neurology, Neurosurgery, Medical Imaging,
connectome   brain networks   focal lesion   surgery   longitudinal   gradients  

Connectomics Reconstruction Associated with Temporal Lobe Lesions and Their Surgical Resection Academic Background The human brain’s structural organization is increasingly conceptualized and analyzed from a network perspective, greatly enhancing understanding of health and disease. In recent years, thanks to advances in neuroimaging technology and...

KATP Channel Mutation Disrupts Hippocampal Network Activity and Nocturnal Gamma Shifts

Medicine, Basic Medical Sciences, Neurology,
DEND syndrome   KATP channel   parvalbumin-positive interneuron   sharp wave ripples   gamma oscillations   epilepsy  

KATP Channel Mutation Disrupts Hippocampal Network Activity and Nocturnal Gamma Wave Changes Research Background ATP-sensitive potassium (KATP) channels are crucial ion channels that link cellular metabolism with electrical activity. Studies have shown that high activity of KATP channels is closely related to a rare disease—Developmental delay, Epi...

Single-Value Brain Activity Scores Reflect Both Severity and Risk Across the Alzheimer’s Continuum

Medicine, Neurology, Medical Imaging,
Single-value scores   Brain activity   Alzheimer's disease   Memory impairment   Imaging biomarkers   Mild cognitive impairment   Diagnostic markers  

Report on the Association Between Single Value Brain Activity Scores and the Progression of Alzheimer’s Disease Introduction Among the elderly population, cognitive decline and brain structural changes are widespread, even among healthy individuals1-3. Episodic memory, crucial for storing, maintaining, and retrieving single-event memories4, is espe...

Low-Intensity Ultrasound Ameliorates Brain Organoid Integration and Rescues Microcephaly Deficits

Medicine, Pediatrics, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Bioengineering, Biophysics,
brain organoid   low-intensity ultrasound   neural progenitor cells   microcephaly   circuit integration  

Low-intensity Ultrasound Promotes Brain Organoid Integration and Improves Microcephaly Defects Background of the Study Brain organoids are generated through the differentiation of pluripotent stem cells (PSCs) and exhibit impressive cellular diversity, capable of mimicking functional networks similar to the human brain. These organoid methods hold ...

Mapping Interictal Discharges Using Intracranial EEG-fMRI to Predict Postsurgical Outcomes

Mapping Interictal Discharges Using Intracranial EEG-fMRI to Predict Postsurgical Outcomes

Medicine, Neurology, Neurosurgery, Medical Imaging, Life Sciences, Biophysics,
epilepsy   surgery   electroencephalography   imaging   seizures   markers  

Using Intracranial EEG-fMRI Mapping of Intermittent Discharges to Predict Epilepsy Surgery Outcomes Background and Objective Epilepsy is a common neurological disorder, and many patients are unresponsive to pharmacological treatments, making surgery one of the primary therapeutic options. However, accurately localizing the seizure onset zone (SOZ) ...

Distinct Virtual Histology of Grey Matter Atrophy in Four Neuroinflammatory Diseases

Medicine, Rheumatology and Immunology, Neurology, Medical Imaging, Life Sciences, Immunology, Biophysics,
virtual histology   grey matter atrophy   multiple sclerosis   NMOSD   MOGAD  

Research Background The core focus of this study is the manifestation of gray matter atrophy in neuroinflammatory diseases. Gray matter atrophy typically appears in four types of neuroinflammatory demyelinating diseases: Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD) positive (AQP4+) and negative (AQP4-) for aquaporin-4 an...