MRI-Guided Staged Bilateral Focused Ultrasound Subthalamotomy for Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder, characterized mainly by motor symptoms such as tremor, rigidity, and bradykinesia. Traditionally, treatments for PD include medication and surgical interventions such as Deep Brain Stimula...

Constructing Human 3D Striatum-Substantia Nigra Organoids to Model Medium Spiny Neuron Projection Deficits in Huntington’s Disease Background Introduction Huntington’s Disease (HD) is a neurodegenerative disorder leading to significant deterioration of the motor system, primarily characterized by defects in medium spiny neurons (MSNs) that project ...

APOE4 Homozygotes Represent a Unique Genotypic Subset of Alzheimer’s Disease Introduction Alzheimer’s disease (AD) is one of the neurodegenerative diseases that modern medicine has yet to conquer, usually with a complex genetic background. While mutations in three genes (APP, PSEN1, and PSEN2) lead to early-onset autosomal dominant Alzheimer’s dise...

The Gating Role of Cortical Transfer of Socially Derived Information in Emotion Recognition Background Introduction Emotion recognition and the subsequent responses are crucial for survival and maintaining social functions. However, how social information is processed to reliably recognize emotions remains unclear. In this new study, the authors re...

Differences in Coupling Between Cortical Networks Related to Arousal in Neural Activity and Hemodynamics Academic Background In the absence of specific sensory inputs or behavioral tasks, the brain generates structured activity patterns. This organized activity is modulated by the state of arousal. The relationship between arousal and cortical acti...

Using Monotonicity-Constrained Deep Geometric Learning to Predict Alzheimer’s Disease Progression Background Introduction Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder that gradually leads to irreversible cognitive decline, eventually resulting in dementia. Early identification and progression prediction of this disease are c...